Genetic Variant of Kalirin Gene Is Associated with Ischemic Stroke in a Chinese Han Population

Table 5

Interaction of three SNPs and environmental risk factors on IS.

Genotype	Gender	IS ()	Control ()	OR (95% CI)
rs7620580
AA	M	109	133	1
	F	90	95	1.156 (0.788–1.697)	0.459
AA + AG	M	110	76	1.766 (1.200–2.600)	0.004
	F	76	58	0.783 (0.434–1.415)	0.418
rs2289843
TT + TA	M	166	158	1
	F	130	130	1.171 (0.822–1.668)	0.383
AA	M	53	51	0.954 (0.591–1.542)	0.849
	F	36	23	1.736 (0.799–3.770)	0.163
rs1708303
AA	M	143	152	1
	F	98	108	1.212 (0.823–1.784)	0.331
AA + AG	M	76	57	1.444 (0.928–2.247)	0.104
	F	68	45	1.182 (0.607–2.303)	0.623
Genotype	Overweight	IS ()	Control ()	OR (95% CI)
rs7620580
AA	Null	129	176
	Yes	69	52	1.839 (1.201–2.816)	0.005
AA + AG	Null	121	97	1.714 (1.206–2.437)	0.003
	Yes	64	37	0.760 (0.399–1.450)	0.406
rs2289843
TT + TA	Null	197	220
	Yes	97	68	1.601 (1.112–2.306)	0.011
AA	Null	53	53	1.080 (0.703–1.660)	0.725
	Yes	36	21	1.113 (0.523–2.368)	0.782
rs1708303
AA	Null	152	193
	Yes	88	67	1.679 (1.145–2.461)	0.008
AA + AG	Null	98	80	1.534 (1.065–2.210)	0.022
	Yes	45	22	1.015 (0.503–2.051)	0.966
Genotype	Smoking	IS ()	Control ()	OR (95% CI)
rs7620580
AA	Null	117	117
	Yes	82	111	0.739 (0.503–1.084)	0.122
AA + AG	Null	112	71	1.577 (1.065–2.336)	0.023
	Yes	74	63	1.008 (0.559–1.819)	0.979
rs2289843
TT + TA	Null	177	159
	Yes	119	129	1.062 (0.612–1.842)	0.832
AA	Null	52	29	1.486 (0.972–2.272)	0.068
	Yes	37	45	0.599 (0.313–1.145)	0.121
rs1708303
AA	Null	145	133
	Yes	96	127	0.693 (0.486–0.988)	0.043
AA + AG	Null	84	55	1.401 (0.926–2.118)	0.11
	Yes	60	47	1.206 (0.647–2.246)	0.556
Genotype	Drinking	IS ()	Control ()	OR (95% CI)
rs7620580
AA	Null	146	153
	Yes	53	75	0.741 (0.487–1.125)	0.159
AA + AG	Null	144	86	1.755 (1.236–2.491)	0.002
	Yes	42	48	0.706 (0.370–1.347)	0.291
rs2289843
TT + TA	Null	224	194
	Yes	72	94	0.777 (0.424–1.425)	0.415
AA	Null	66	45	1.286 (0.879–1.880)	0.195
	Yes	23	29	0.757 (0.371–1.542)	0.443
rs1708303
AA	Null	182	168
	yes	59	92	0.592 (0.401–0.873)	0.008
AA + AG	null	108	71	1.404 (0.974–2.024)	0.069
	yes	36	31	1.29 (0.649–2.562)	0.468