Table 5: Interaction of three SNPs and environmental risk factors on IS.

GenotypeGenderIS ()Control ()OR (95% CI)

rs7620580
AAM1091331
F90951.156 (0.788–1.697)0.459
AA + AGM110761.766 (1.200–2.600)0.004
F76580.783 (0.434–1.415)0.418
rs2289843
TT + TAM1661581
F1301301.171 (0.822–1.668)0.383
AAM53510.954 (0.591–1.542)0.849
F36231.736 (0.799–3.770)0.163
rs1708303
AAM1431521
F981081.212 (0.823–1.784)0.331
AA + AG
 
M76571.444 (0.928–2.247)0.104
F68451.182 (0.607–2.303)0.623

GenotypeOverweightIS ()Control ()OR (95% CI)

rs7620580
AANull129176
Yes69521.839 (1.201–2.816)0.005
AA + AGNull121971.714 (1.206–2.437)0.003
Yes64370.760 (0.399–1.450)0.406
rs2289843
TT + TANull197220
Yes97681.601 (1.112–2.306)0.011
AANull53531.080 (0.703–1.660)0.725
Yes36211.113 (0.523–2.368)0.782
rs1708303
AANull152193
Yes88671.679 (1.145–2.461)0.008
AA + AG
 
Null98801.534 (1.065–2.210)0.022
Yes45221.015 (0.503–2.051)0.966

GenotypeSmokingIS ()Control ()OR (95% CI)

rs7620580
AANull117117
Yes821110.739 (0.503–1.084)0.122
AA + AGNull112711.577 (1.065–2.336)0.023
Yes74631.008 (0.559–1.819)0.979
rs2289843
TT + TANull177159
Yes1191291.062 (0.612–1.842)0.832
AANull52291.486 (0.972–2.272)0.068
Yes37450.599 (0.313–1.145)0.121
rs1708303
AANull145133
Yes961270.693 (0.486–0.988)0.043
AA + AG
 
Null84551.401 (0.926–2.118)0.11
Yes60471.206 (0.647–2.246)0.556

GenotypeDrinkingIS ()Control ()OR (95% CI)

rs7620580
AANull146153
Yes53750.741 (0.487–1.125)0.159
AA + AGNull144861.755 (1.236–2.491)0.002
Yes42480.706 (0.370–1.347)0.291
rs2289843
TT + TANull224194
Yes72940.777 (0.424–1.425)0.415
AANull66451.286 (0.879–1.880)0.195
Yes23290.757 (0.371–1.542)0.443
rs1708303
AANull182168
yes59920.592 (0.401–0.873)0.008
AA + AG
 
null108711.404 (0.974–2.024)0.069
yes36311.29 (0.649–2.562)0.468