Genetic Variant of Kalirin Gene Is Associated with Ischemic Stroke in a Chinese Han Population
Table 6
Analysis of kalirin genotypic association with IS in subgroups.
rs7620580
Gender
Genotype
Woman
Man
OR (95% CI)
OR (95% CI)
OR (95% CI)
OR (95% CI)
AG
1.368 (0.866–2.162)
1.988 (1.035–3.816)▲
1.723 (1.154–2.572)▲▲
1.776 (1.096–2.877)
GG
1.583 (0.433–5.796)
2.236 (0.410–12.201)
2.135 (0.864–5.277)
3.661 (1.215–11.036)
Recessive
1.397 (0.387–5.048)
1.682 (0.319–8.876)
1.716 (0.704–4.179)
2.895 (0.982–8.541)
Additive
1.334 (0.896–1.987)
1.804 (1.032–3.152)▲
1.608 (1.158–2.233)▲▲
1.832 (1.235–2.719)▲▲
Dominant
1.383 (0.884–2.163)
2.007 (1.062–3.793)▲
1.766 (1.200–2.600)▲▲
1.923 (1.206–3.067)▲▲
BMI
Genotype
BMI 25 kg/m2
BMI ≥ 25 kg/m2
OR (95% CI)
OR (95% CI)
OR (95% CI)
OR (95% CI)
AA
1
1
1
1
AG
1.658 (1.157–2.377)▲▲
1.598 (0.999–2.557)
1.302 (0.744–2.278)
1.966 (0.887–4.357)
GG
2.200 (0.866–5.462)
3.055 (0.918–10.166)
1.319 (0.367–4.744)
4.130 (0.858–19.874)
Recessive
1.802 (0.734–4.422)
2.565 (0.781–8.424)
1.181 (0.335–4.157)
3.105 (0.681–14.156)
Additive
1.593 (1.175–2.160)▲▲
1.651 (1.112–2.451)▲
1.236 (0.780–1.959)
1.999 (1.077–3.711)▲
Dominant
1.703 (1.200–2.416)▲▲
1.699 (1.077–2.680)▲
1.304 (0.758–2.241)
2.188 (1.019–4.700)▲
rs2289843
Gender
Genotype
Woman
Man
OR (95% CI)
OR (95% CI)
OR (95% CI)
OR (95% CI)
TT
1
1
1
1
TA
1.070 (0.643–1.779)
1.443 (0.687–3.033)
1.203 (0.763–1.895)
1.421 (0.825–2.446)
AA
1.635 (0.842–3.175)
2.782 (1.134–6.826)▲
1.113 (0.656–1.891)
1.208 (0.645–2.264)
Recessive
1.565 (0.879–2.787)
2.186 (1.035–4.620)▲
0.989 (0.636–1.539)
0.970 (0.573–1.642)
Additive
1.250 (0.903–1.730)
1.658 (1.059–2.595)▲
1.059 (0.813–1.380)
1.108 (0.810–1.515)
Dominant
1.192 (0.734–1.936)
1.765 (0.872–3.570)
1.172 (0.765–1.796)
1.344 (0.810–2.231)
BMI
Genotype
BMI 25kg/m2
BMI ≥ 25 kg/m2
OR (95% CI)
OR (95% CI)
OR (95% CI)
OR (95% CI)
TT
1
1
1
1
TA
1.033 (0.692–1.541)
1.134 (0.678–1.897)
1.490 (0.782–2.839)
1.889 (0.733–4.866)
AA
1.129 (0.686–1.858)
1.370 (0.723–2.596)
1.548 (0.737–3.252)
1.569 (0.581–4.241)
Recessive
1.106 (0.722–1.693)
1.266 (0.730–2.197)
1.202 (0.646–2.236)
1.071 (0.474–2.420)
Additive
1.060 (0.827–1.357)
1.167 (0.850–1.602)
1.250 (0.860–1.817)
1.238 (0.754–2.034)
Dominant
1.059 (0.724–1.548)
1.197 (0.736–1.947)
1.510 (0.818–2.756)
1.741 (0.740–4.097)
rs1708303
Gender
Genotype
Woman
Man
OR (95% CI)
OR (95% CI)
OR (95% CI)
OR (95% CI)
AA
1
1
1
1
AG
1.613 (0.996–2.612)
1.663 (0.846–3.272)
1.444 (0.947–2.202)
1.497 (0.901–2.487)
GG
2.204 (0.644–7.548)
1.191 (0.236–6.015)
1.063 (0.261–4.330)
0.875 (0.168–4.564)
Recessive
1.886 (0.556–6.394)
1.020 (0.205–5.072)
0.953 (0.235–3.863)
0.778 (0.150–4.034)
Additive
1.566 (1.045–2.345)▲
1.414 (0.809–2.470)
1.332 (0.914–1,941)
1.331 (0.848–2.090)
Dominant
1.665 (1.046–2.652)▲
1.602 (0.837–3.068)
1.417 (0.938–2.141)
1.447 (0.881–2.374)
BMI
Genotype
BMI 25 kg/m2
BMI ≥ 25 kg/m2
OR (95% CI)
OR (95% CI)
OR (95% CI)
OR (95% CI)
AA
1
1
1
1
AG
1.590 (1.094–2.309)▲
1.368 (0.841–2.227)
1.450 (0.783–2.686)
2.435 (1.003–5.912)▲
GG
1.261 (0.433–3.674)
0.969 (0.248–3.781)
3.807 (0.434–33.355)
2.035 (0.164–25.291)
Recessive
1.086 (0.375–3.140)
0.880 (0.227–3.417)
3.437 (0.395–29.930)
1.651 (0.136–20.089)
Additive
1.431 (1.036–1.978)▲
1.232 (0.813–1.867)
1.564 (0.912–2.683)
2.095 (0.962–4.562)
Dominant
1.561 (1.086–2.244)▲
1.329 (0.829–2.131)
1.557 (0.854–2.840)
2.397 (1.018–5.644)▲
adjusted for age, SBP, and drinking history in men; adjusted for age, SBP, LDL-C, and smoking history in women; adjusted for age, SBP, LDL-C, and smoking history in BMI 25 kg/m2; adjusted for age, SBP, LDL-C, and smoking history in BMI ≥ 25 kg/m2; < 0.05, < 0.01.
