Table 6: Analysis of kalirin genotypic association with IS in subgroups.

rs7620580

Gender

GenotypeWomanMan
OR (95% CI)OR (95% CI)OR (95% CI)OR (95% CI)

AG1.368 (0.866–2.162)1.988 (1.035–3.816)1.723 (1.154–2.572)▲▲1.776 (1.096–2.877)
GG1.583 (0.433–5.796)2.236 (0.410–12.201)2.135 (0.864–5.277)3.661 (1.215–11.036)
Recessive1.397 (0.387–5.048)1.682 (0.319–8.876)1.716 (0.704–4.179)2.895 (0.982–8.541)
Additive1.334 (0.896–1.987)1.804 (1.032–3.152)1.608 (1.158–2.233)▲▲1.832 (1.235–2.719)▲▲
Dominant1.383 (0.884–2.163)2.007 (1.062–3.793)1.766 (1.200–2.600)▲▲1.923 (1.206–3.067)▲▲

BMI

GenotypeBMI 25 kg/m2BMI ≥ 25 kg/m2
OR (95% CI)OR (95% CI)OR (95% CI)OR (95% CI)

AA1111
AG1.658 (1.157–2.377)▲▲1.598 (0.999–2.557)1.302 (0.744–2.278)1.966 (0.887–4.357)
GG2.200 (0.866–5.462)3.055 (0.918–10.166)1.319 (0.367–4.744)4.130 (0.858–19.874)
Recessive1.802 (0.734–4.422)2.565 (0.781–8.424)1.181 (0.335–4.157)3.105 (0.681–14.156)
Additive1.593 (1.175–2.160)▲▲1.651 (1.112–2.451)1.236 (0.780–1.959)1.999 (1.077–3.711)
Dominant1.703 (1.200–2.416)▲▲1.699 (1.077–2.680)1.304 (0.758–2.241)2.188 (1.019–4.700)

rs2289843

Gender

GenotypeWomanMan
OR (95% CI)OR (95% CI)OR (95% CI)OR (95% CI)

TT1111
TA1.070 (0.643–1.779)1.443 (0.687–3.033)1.203 (0.763–1.895)1.421 (0.825–2.446)
AA1.635 (0.842–3.175)2.782 (1.134–6.826)1.113 (0.656–1.891)1.208 (0.645–2.264)
Recessive1.565 (0.879–2.787)2.186 (1.035–4.620)0.989 (0.636–1.539)0.970 (0.573–1.642)
Additive1.250 (0.903–1.730)1.658 (1.059–2.595)1.059 (0.813–1.380)1.108 (0.810–1.515)
Dominant1.192 (0.734–1.936)1.765 (0.872–3.570)1.172 (0.765–1.796)1.344 (0.810–2.231)

BMI

GenotypeBMI 25kg/m2BMI ≥ 25 kg/m2
OR (95% CI)OR (95% CI)OR (95% CI)OR (95% CI)

TT1111
TA1.033 (0.692–1.541)1.134 (0.678–1.897)1.490 (0.782–2.839)1.889 (0.733–4.866)
AA1.129 (0.686–1.858)1.370 (0.723–2.596)1.548 (0.737–3.252)1.569 (0.581–4.241)
Recessive1.106 (0.722–1.693)1.266 (0.730–2.197)1.202 (0.646–2.236)1.071 (0.474–2.420)
Additive1.060 (0.827–1.357)1.167 (0.850–1.602)1.250 (0.860–1.817)1.238 (0.754–2.034)
Dominant1.059 (0.724–1.548)1.197 (0.736–1.947)1.510 (0.818–2.756)1.741 (0.740–4.097)

rs1708303

Gender

GenotypeWomanMan
OR (95% CI)OR (95% CI)OR (95% CI)OR (95% CI)

AA1111
AG1.613 (0.996–2.612)1.663 (0.846–3.272)1.444 (0.947–2.202)1.497 (0.901–2.487)
GG2.204 (0.644–7.548)1.191 (0.236–6.015)1.063 (0.261–4.330)0.875 (0.168–4.564)
Recessive1.886 (0.556–6.394)1.020 (0.205–5.072)0.953 (0.235–3.863)0.778 (0.150–4.034)
Additive1.566 (1.045–2.345)1.414 (0.809–2.470)1.332 (0.914–1,941)1.331 (0.848–2.090)
Dominant1.665 (1.046–2.652)1.602 (0.837–3.068)1.417 (0.938–2.141)1.447 (0.881–2.374)

BMI

GenotypeBMI 25 kg/m2BMI ≥ 25 kg/m2
OR (95% CI)OR (95% CI)OR (95% CI)OR (95% CI)

AA1111
AG1.590 (1.094–2.309)1.368 (0.841–2.227)1.450 (0.783–2.686)2.435 (1.003–5.912)
GG1.261 (0.433–3.674)0.969 (0.248–3.781)3.807 (0.434–33.355)2.035 (0.164–25.291)
Recessive1.086 (0.375–3.140)0.880 (0.227–3.417)3.437 (0.395–29.930)1.651 (0.136–20.089)
Additive1.431 (1.036–1.978)1.232 (0.813–1.867)1.564 (0.912–2.683)2.095 (0.962–4.562)
Dominant1.561 (1.086–2.244)1.329 (0.829–2.131)1.557 (0.854–2.840)2.397 (1.018–5.644)

adjusted for age, SBP, and drinking history in men; adjusted for age, SBP, LDL-C, and smoking history in women; adjusted for age, SBP, LDL-C, and smoking history in BMI 25 kg/m2; adjusted for age, SBP, LDL-C, and smoking history in BMI ≥ 25 kg/m2; < 0.05, < 0.01.