Basal and Activated Calcium Sensitization Mediated by RhoA/Rho Kinase Pathway in Rats with Genetic and Salt Hypertension

Figure 2

Dose-dependent MAP changes elicited by increasing cumulative doses of fasudil in rats with intact RAS and SNS: WKY and SHR rats ((a) and (d)), HanSD and TGR animals ((b) and (e)), and salt-sensitive (SS/Jr) and salt-resistant (SR/Jr) Dahl rats fed either low-salt (LS) or high-salt (HS) diet ((c) and (f)). Relative MAP changes (d, e, and f) are expressed as a percentage of initial MAP values (Experiment ). Data are mean ± SEM; for number of rats see Table 1. versus normotensive controls (WKY, HanSD, or SR/Jr-HS); versus corresponding rat strain fed a low-salt diet. For the statistical analysis see also Table 1.

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