Basal and Activated Calcium Sensitization Mediated by RhoA/Rho Kinase Pathway in Rats with Genetic and Salt Hypertension

Figure 3

Dose-dependent MAP changes (mmHg) induced by increasing BAY K8644 doses in the absence and in the presence of fasudil in rats with inhibited RAS and SNS. (a) WKY and SHR rats, (b) HanSD and TGR animals, (c) salt-sensitive (SS/Jr) Dahl rats fed either low-salt (LS) or high-salt (HS) diet, and (d) salt-resistant (SR/Jr) animals (Experiment ). Data are mean ± SEM; for number of rats see Table 3. The statistical analysis revealed significant differences for factors strain and treatment in maximal responses (max) of SHR, TGR, and salt-sensitive Dahl rats compared to their controls but not in other parameters (log ED50 and slope); for detailed statistical analysis see Table 4.

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