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BioMed Research International
Volume 2017 (2017), Article ID 8403184, 8 pages
Review Article

The Roles of Thrombospondins in Hemorrhagic Stroke

Department of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China

Correspondence should be addressed to Zongyi Xie

Received 12 February 2017; Revised 7 May 2017; Accepted 26 September 2017; Published 30 October 2017

Academic Editor: Sheng Chen

Copyright © 2017 Xuan Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hemorrhagic stroke is a devastating cerebrovascular disease with significant morbidity and mortality worldwide. Thrombospondins (TSPs), as matricellular proteins, belong to the TSP family which is comprised of five members. All TSPs modulate a variety of cellular functions by binding to various receptors. Recently, TSPs gained attention in the area of hemorrhagic stroke, especially TSP-1. TSP-1 participates in angiogenesis, the inflammatory response, apoptosis, and fibrosis after hemorrhagic stroke through binding to various molecules including but not limited to CD36, CD47, and TGF-β. In this review, we will discuss the roles of TSPs in hemorrhagic stroke and focus primarily on TSP-1.