Protein Arginine Methyltransferase 2 Inhibits Angiotensin II-Induced Proliferation and Inflammation in Vascular Smooth Muscle Cells

Figure 3

PRMT2 overexpression attenuated Ang II-induced VSMCs proliferation. (a) PRMT2 protein level. Cells were transfected with pcDNA3.1-PRMT2 for 48 hours. (b-f) After transfected with pcDNA3.1-PRMT2 for 24 hours, VSMCs were treated with 100 nM Ang II for 24 hours. (b) PRMT2 protein level; (c) PCNA protein level; (d) cell viability; (e) representative results of cell cycle distribution; (f) cell number. Ang II represents angiotensin II; VSMCs represent vascular smooth muscle cells. P<0.05 versus vector group, ^#P<0.05 versus Ang II group. n=3 independent experiments.

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