Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity

Figure 3

DanioScope system and EthoVision XT9.0 analysis platform. A. DanioScope recognizes the embryos and can analyze videos with multiple animals simultaneously and DanioScope reports back (table A) the following parameters: burst activity (percentage of time the embryo was moving), Inactivity (percentage of time of inactivity); burst duration (total time spent active); inactivity duration (total time spent inactive); burst count (number of times the embryo moved); Burst count/per minute. B. DanioScope measures activity in the heart of each larvae, from this activity the heartbeat in beats per second or per minute is extracted graph B. C. Flow activity can be measured in both blood vessels and the gut.