Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity

Table 1

Comparison of cardiotoxicities for several clinical drugs on human and zebrafish.

Drug	Effect on human	Effect on zebrafish
Doxorubicin [25] 5-fluorouracil Terfenadine [26]; Lidocaine	Cardiomyopathy, arrhythmia, negative inotropic effects (affect the muscle contraction), or QT prolongation.	Bradycardia, Acute atrioventricular block (AV block), Slow circulation
Clomipramine [26]	QT prolongation	Pericardial edema, hemorrhage, bradycardia, and death at higher concentrations
Quinidine	QT prolongation	AV block
Thioridazine
Metoprolol [26]	Bradycardia	Pericardial edema
Mexiletine	Decreased heart rate	Decreased heart rate
Phenytoin