Madelung’s Disease: Lipectomy or Liposuction?

Table 1

41 literature sources of Madelung’s disease from 2000 to 2015 with complete materials of treatment.

Published date	Authors	Cases	Male : female	Age or average age	Treatment			After treatment
					Lipectomy	Liposuction	Other	Relapse (follow-up times)	No relapse (follow-up times)	Unknown
2015	Azuma et al.	1	1 : 0	74	1	0	0	0	0	1
	Andou et al.	1	1 : 0	51	0	0	1 (intralipotherapy)	0	1 (4 years)	0
2015	Kang et al.	1	1 : 0	64	1	0	0	0	0	1
2015	Zielińska-Kaźmierska et al.	1	1 : 0	46	1	0	0	0	0	1
	Ozderya et al.	1	1 : 0	29	0	0	1 (medical therapy)	0	1 (3 years)	0
2014	Jang et al.	1	1 : 0	66	1	0	0	0	0	1
2014	Celentano et al.	1	1 : 0	51	1	0	0	0	1 (36 months)	0
2014	Z. Pinnella and J. Pinnella	1	1 : 0	52	1	0	0	0	1 (30 months)	0
	Scevola et al.	2	2 : 0	47	0	0	2 (intralipotherapy)	0	0	2
2014	Orasmo et al.	1	1 : 0	48	1	0	0	0	0	1
	Hundeshagen et al.	2	2 : 0	58.5	2	0	0	0	2 (8–13 months)	0
2014	Tai et al.	1	1 : 0	54	1	0	0	1 (2 years)	0	0
2014	Shibasaki et al.	1	1 : 0	47	1	0	0	0	0	1
	Agostini et al.	1	1 : 0	62	1	1	0	0	1 (1 year)	0
2013	Nikolić et al.	1	1 : 0	51	1	0	0	1 (3 years)	0	0
2013	Kang and Kim	1	0 : 1	76	1	0	0	0	0	1
2013	Ardeleanu et al.	1	1 : 0	55	1	0	0	0	0	1
2013	Klobucnikova et al.	2	2 : 0	58	2	0	0	0	0	2
	Borriello et al.	1	0 : 1	59	1	0	0	1 (malignant)	0	0
2012	Lee et al.	1	1 : 0	50	1	0	0	0	1 (10 months)	0
2012	Sia et al.	1	1 : 0	45	1	0	0	0	1 (1 week)	0
2012	Subash et al.	1	1 : 0	49	1	0	0	0	0	1
2012	Friedl et al.	1	0 : 1	55	0	0	1 (medical therapy)	0	0	1
	Tufan et al.	1	1 : 0	56	0	0	1 (medical therapy)	0	0	1
2012	Mevio et al.	3	3 : 0	59.3	3	0	0	0	0	3
2012	Di Candia and Cormack	1	1 : 0	34	1	0	0	0	0	1
2011	Albu	1	1 : 0	59	1	0	0	0	1 (2 years)	0
2011	Lee et al.	1	1 : 0	71	1	0	0	0	1 (2.4 years)	0
2011	Ampollini and Carbognani	1	1 : 0	45	0	0	1 (medical therapy)	0	0	1
2010	Milisavljevic et al.	1	1 : 0	58	1	0	0	0	1 (1 year)	0
2009	Juric and Carapina	1	1 : 0	69	0	0	1 (medical therapy)	0	0	1
2009	Alameda et al.	1	1 : 0	55	1	0	0	0	0	1
2009	Tekin and Ogetman	1	1 : 0	26	1	0	0	0	0	1
2009	Lee et al.	1	1 : 0	64	1	0	0	0	0	1
2008	Verna et al.	4	2 : 2	55.25	3	1	0	0	0	4
	Tan and Ergen	1	0 : 1	20	1	1	0	0	1 (22 months)	0
2007	Bulum et al.	1	1 : 0	51	1	0	0	0	0	1
2007	Ali and Kishore	1	1 : 0	53	1	0	0	0	1 (6 months)	0
2006	Lopez-Ceres et al.	1	0 : 1	57	1	0	0	0	0	1
	Conroy	1	1 : 0	51	1	1	0	0	0	1
2005	Colella et al.	1	1 : 0	44	1	0	0	0	0	1
2004	Uglešić et al.	1	1 : 0	53	1	0	0	0	1 (5 months)	0
2004	González-García et al.	2	2 : 0	51.5	2	0	0	0	2 (1 and 10 years)	0
	Constantinidis et al.	11	10 : 1	47	11	11	0	2 (1 and 1.5 years)	9	0
2003	Verhelle et al.	5	4 : 1	52.5	5	0	0	1 (10–48 years)	4	0
2002	Guastella et al.	2	1 : 1	59.5	2	0	0	0	1 (18 months)	1
2001	Ujpaál et al.	31	29 : 2	41.5	31	0	0	0	11 (17.1 years)	20
2001	Faga et al.	1	1 : 0	51	0	1	0	1 (1 year)	0	0
	Nielsen et al.	1	0 : 1	50	1	1	0	0	0	1
2001	Fischer et al.	1	1 : 0	43	0	0	1 (intratumoral injection)	0	0	1
	Payne	1	1 : 0	69	1	1	0	0	1 (1 year)	0
2000	Vargas-Díez et al.	1	1 : 0	59	1	0	0	0	1 (6 months)	0
Sum		106	93 : 13		95	18	9	7	44	55
Average				52.9
Percentage					0.8962	0.1698	0.0849

A total of 41 studies published from 2005 to 2015 included complete patient characteristics and treatment descriptions and were selected for review [1–3, 8, 10–57]. This patient had a relapse 4 years after treatment, then surgical procedure was performed, and there was no recurrence of the lipomatosis after a 32-month follow-up. The lipomatosis of 2 patients remained unchanged in 4-month to 3-year follow-up. These 2 patients both had successful previous surgical excision. This patient had failed liposuction before. Patients in these cases were submitted to liposuction combined with lipectomy. Malignant happened in this case.