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BioMed Research International
Volume 2018, Article ID 4258387, 29 pages
https://doi.org/10.1155/2018/4258387
Review Article

Modelling Cooperative Tumorigenesis in Drosophila

1Department of Biochemistry and Genetics, La Trobe Institute of Molecular Science, La Trobe University, Melbourne, VIC, Australia
2Department of Molecular, Cellular and Developmental Neurobiology, Cajal Institute (CSIC), Avenida Doctor Arce, No. 37, 28002 Madrid, Spain

Correspondence should be addressed to Helena E. Richardson; ua.ude.ebortal@nosdrahcir.h

Received 24 November 2017; Accepted 21 January 2018; Published 6 March 2018

Academic Editor: Daniela Grifoni

Copyright © 2018 Helena E. Richardson and Marta Portela. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The development of human metastatic cancer is a multistep process, involving the acquisition of several genetic mutations, tumour heterogeneity, and interactions with the surrounding microenvironment. Due to the complexity of cancer development in mammals, simpler model organisms, such as the vinegar fly, Drosophila melanogaster, are being utilized to provide novel insights into the molecular mechanisms involved. In this review, we highlight recent advances in modelling tumorigenesis using the Drosophila model, focusing on the cooperation of oncogenes or tumour suppressors, and the interaction of mutant cells with the surrounding tissue in epithelial tumour initiation and progression.