BioMed Research International

Drosophila Models of Human Disease


Status
Published

Lead Editor

1University of Bologna, Bologna, Italy

2Centro de Biologia Molecular “Severo Ochoa”, Madrid, Spain

3Peter MacCallum Cancer Centre, Melbourne, Australia


Drosophila Models of Human Disease

Description

The fruit fly Drosophila melanogaster has proven to be a golden model for basic biological research. Across the years, its potential as a tool for deciphering the molecular networks at the basis of human disease has become more and more acknowledged. Uninterrupted efforts of the Drosophila research community have been dedicated to develop new genetic systems aimed at investigating organ, tissue, and cellular processes at an increasing level of precision. As a result, the fruit fly now serves as a model not only for basic genetic research, but also for an extraordinarily diverse series of human diseases, from cancer to neurodegeneration and from developmental disorders to drug discovery. As cellular and molecular mechanisms governing organogenesis have shown to be highly conserved between Drosophila and humans, and the fruit fly has functional homologues of most part of the human disease genes, we anticipate that this aspect of Drosophila research will definitely expand in the future.

We invite investigators to contribute original research articles, as well as review articles and opinion papers that address mechanisms involved in human disease using the Drosophila model.

Potential topics include but are not limited to the following:

  • Developmental disorders
  • Metabolic disease
  • Organ disease
  • Stem cells and regenerative medicine
  • Cancer
  • Neurological disease
  • Drug discovery

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 7214974
  • - Editorial

Drosophila Models of Human Disease

Louise Cheng | Antonio Baonza | Daniela Grifoni
  • Special Issue
  • - Volume 2018
  • - Article ID 3570830
  • - Research Article

Cinnamaldehyde Improves Lifespan and Healthspan in Drosophila melanogaster Models for Alzheimer’s Disease

Hanh M. Pham | Anna Xu | ... | Mahtab Jafari
  • Special Issue
  • - Volume 2018
  • - Article ID 6726874
  • - Research Article

Rhodiola rosea Improves Lifespan, Locomotion, and Neurodegeneration in a Drosophila melanogaster Model of Huntington’s Disease

Jasmin G. J. Arabit | Rami Elhaj | ... | Mahtab Jafari
  • Special Issue
  • - Volume 2018
  • - Article ID 5697436
  • - Review Article

Modeling Renal Disease “On the Fly”

Cassandra Millet-Boureima | Jessica Porras Marroquin | Chiara Gamberi
  • Special Issue
  • - Volume 2018
  • - Article ID 5195416
  • - Review Article

Using Drosophila Models of Amyloid Toxicity to Study Autophagy in the Pathogenesis of Alzheimer’s Disease

Louise O’Keefe | Donna Denton
  • Special Issue
  • - Volume 2018
  • - Article ID 5473180
  • - Review Article

Learning on the Fly: The Interplay between Caspases and Cancer

Derek Cui Xu | Lewis Arthurton | Luis Alberto Baena-Lopez
  • Special Issue
  • - Volume 2018
  • - Article ID 1417528
  • - Review Article

Drosophila melanogaster as a Model for Diabetes Type 2 Progression

Jéssica P. Álvarez-Rendón | Rocío Salceda | Juan R. Riesgo-Escovar
  • Special Issue
  • - Volume 2018
  • - Article ID 5065190
  • - Review Article

Drosophila melanogaster Models of Friedreich’s Ataxia

P. Calap-Quintana | J. A. Navarro | ... | J. V. Llorens
  • Special Issue
  • - Volume 2018
  • - Article ID 7359267
  • - Review Article

Drosophila as a Model System to Study Cell Signaling in Organ Regeneration

Sara Ahmed-de-Prado | Antonio Baonza
  • Special Issue
  • - Volume 2018
  • - Article ID 7152962
  • - Review Article

Drosophila as a Model System to Study Nonautonomous Mechanisms Affecting Tumour Growth and Cell Death

Jean-Philippe Parvy | Joseph A. Hodgson | Julia B. Cordero
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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