Comparison and Noise Suppression of the Transmitted and Reflected Photoplethysmography Signals

Li, Suyi; Liu, Lijia; Wu, Jiang; Tang, Bingyi; Li, Dongsheng

doi:https://doi.org/10.1155/2018/4523593

BioMed Research International

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Abstract Introduction Materials and Methods Results and Discussion Conclusion Abbreviations Data Availability Ethical Approval Consent Conflicts of Interest Authors’ Contributions Acknowledgments References Copyright Related Articles

Research Article | Open Access

Volume 2018 | Article ID 4523593 | https://doi.org/10.1155/2018/4523593

Comparison and Noise Suppression of the Transmitted and Reflected Photoplethysmography Signals

Suyi Li,¹Lijia Liu,¹Jiang Wu,¹Bingyi Tang,¹and Dongsheng Li²

Academic Editor: Momiao Xiong

Received09 May 2018

Revised31 Aug 2018

Accepted12 Sept 2018

Published26 Sept 2018

Abstract

The photoplethysmography (PPG) is inevitably corrupted by many kinds of noise no matter whether its acquisition mode is transmittance or reflectance. To enhance the quality of PPG signals, many studies have made great progress in PPG denoising by adding extra sensors and developing complex algorithms. Considering the reasonable cost, compact size, and real-time and easy implementation, this study proposed a simple real-time denoising method based on double median filters which can be integrated in microcontroller of commercial or portable pulse oximeters without adding extra hardware. First, we used the boundary extension to preserve the signal boundary distortion and designed a first median filter with the time window at approximately 78 ms to eliminate the high-frequency components of the signal. Then, through the second median filter with a time window which was about 780 ms, we estimated the low-frequency components. Finally, we removed the estimated low-frequency components from the signal to obtain the denoised signal. Through comparing the multiple sets of signals under calmly sitting and slightly moving postures, the PPG signals contained noises no matter whether collected by the transmittance-mode or the reflectance-mode. To evaluate the proposed method, we conducted measured, simulated experiments and a strong noisy environment experiment. Through comparing the morphology distortions, frequency spectra, and the signal-to-noise ratios (SNRs), the results showed that the proposed method can suppress noise effectively and preserve the essential morphological features from PPG signals. As a result, the proposed method can enhance the quality of PPG signals and, thus, can contribute to the improvement of the calculation accuracy of the subsequent physiological parameters. In addition, the proposed method could be a good choice to address the real-time noise reduction of portable PPG measuring instruments.

1. Introduction

The initial clinical application of photoplethysmography (PPG) is to monitor the noninvasive blood oxygen saturation (SpO₂) and, furthermore, it has been widely used in the assessment of the cardiovascular, respiratory, and hematological status [1, 2].

The principle of PPG acquisition is to emit different wavelengths of LED lights on the epidermis and to receive the transmitted or reflected lights by using the photoelectric sensors. The received optical density will vary as the blood volume of the measuring site changes and can be recorded by using electrical signals to form PPG which can be used to derive the approximate formula for SpO₂ estimation based on Lambert–Beer law [3, 4]. Compared with the fingertip transmittance-mode PPG monitoring, the measuring site and the motion status are relatively flexible under the reflectance-mode, and studies have shown that the reflectance-mode way can achieve better SpO₂ measurement accuracy during the perfusion [5, 6]. However, finger-tip transmittance pulse oximeters are still playing the important role in clinical applications because of their stable performance, easy operation, and low cost [7].

No matter whether the PPG signal is obtained by using transmittance-mode or reflectance-mode, it will inevitably be corrupted by many kinds of noise such as high-frequency noise, power line interference, baseline drift, and motion artifact (MA), and these noises will affect the pulse rate analysis and SpO₂ measurement accuracy [8]. To date, many studies have proposed noise suppression methods for PPG signals. The high-frequency noise in PPG signal could be eliminated by empirical mode decomposition (EMD) method [9]. The power line interference could be reduced by a wavelet denoising method integrated in DSP [10]. The baseline drift could be estimated by applying the wavelet multiresolution principle [11, 12]. A real-time method based on a contour analysis was implemented on a 32-bit ARM core microcontroller to detect the pulse waveform segmentation and artifact [13]. Due to the fact that MA can significantly distort the morphology of the PPG signal, it is worthwhile to focus on the removal methods. One of the commonly used approaches is through adding the extra hardware, such as using the accelerometer as the reference signal for MA cancellation [14–16]. Another way is through designing the denoising algorithms, including adaptive filter [17, 18], wavelet-based method [19, 20], independent component analysis (ICA) [21, 22], singular value decomposition (SVD) [23], cycle-by-cycle Fourier series analysis [24, 25], and higher order statistics [26].

We have seen the significant progress in the domain of PPG denoising. However, the above methods include adding extra hardware and requiring high-end microcontroller or host computer where the complicated algorithm needs to run and the PPG data needs to be transferred to, which are all complicated and can be inapplicable due to the high market share of the traditional pulse oximeter. Therefore, considering the low cost, compact size, and real-time and easy implementation, a denoising method based on double median filters is proposed in this study. The proposed denoising method can run on the ordinary microcontroller and can be real-time. In other words, it is convenient enough to be embedded in commercial two-wavelength pulse oximeters without changing any hardware or transmitting the data to the host computer for processing.

This study will first compare the reflected PPG with the transmitted PPG signals under calmly sitting and slightly moving postures and describe the principle of the denoising method based on double median filters and its implementation steps. Then, we will conduct experiments using measured signals, simulated signals, and the noisy signals collected under the strong noise environment, respectively. Finally, we will evaluate the performance of the proposed denoising method through comparing the morphology distortions, frequency spectra, and SNRs.

2. Materials and Methods

2.1. The Measurement Devices

Most pulse oximeters are designed based on the good linear relationship between the oxygen saturation and the relative light intensity of the 660 nm (red-light) and 940 nm (IR-light) wavelengths received by the photodetector. The reflective pulse oximeter used in the experiment was provided by Tianjin Synopsis Technology Co., Ltd., China. The raw data can be collected by the data acquisition software provided by the company with the sampling frequency of 100 Hz. The emitter and photodetector are adjacent to each other with the measuring site side by side, as shown in Figure 1(a). The prototype of transmitted pulse oximeter was developed by Jilin University, China, with the sampling frequency of 128 Hz. The emitter and photodetector are opposite to each other with the measuring site in-between, as shown in Figure 1(b). When the red-light and IR-light pass through the measuring site, they will be received by the photodetector to produce PPG signals, as shown in Figure 1.

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(b)

2.2. PPG Signals Acquisition

A total of 10 volunteers participated in the experiment, 7 males and 3 females. The mean age (mean ± std) was 26.20 ± 5.14 and the mean body mass index (BMI ± std) was 21.79 ± 3.40. The volunteers were informed about the study before the data was obtained. Table 1 shows their basic personal information.

We used the above two devices to collect their multiple sets of middle fingertips PPG signals under the calmly sitting and slightly moving postures. Hardware filters can eliminate some of the noise in PPG signals, but the signal was still affected by respiration, random noise, and motion artifacts during the measuring procedure, resulting in morphological distortions in PPG signals. For the clarity of the subsequent comparisons, the amplitude range of the signal was normalized from 0 to 1 by usingwhere , is the data length, is the normalized signal, and is the raw signal.

We employed 2000 representative samples which were taken from the IR signals acquired by the transmittance and by the reflectance oximeter, respectively, as shown in Figure 2. The quality of the PPG signal under the sitting posture is relatively good. Figure 2(a) illustrates the transmitted signal which contained a small amount of high-frequency noise; Figure 2(b) shows the reflected PPG signal with mild baseline wander which may be caused by respiration. Under the slightly moving posture, the morphologies of the transmitted and reflected signal are both distorted due to the motion artifacts, as shown in Figures 2(c) and 2(d), respectively. Therefore, it is necessary to suppress the noise and to preserve the essential morphological features, enhancing the signal quality to improve the calculation accuracy of the physiological parameters subsequently.

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(b)

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2.3. The Denoising Method Based on Double Median Filters

According to the frequency of the major component of the PPG signal and the spectral comparisons of the reflected and the transmitted signals under the calmly sitting and slightly moving postures, we designed a noise reduction method based on double median filters.

The median filter is a nonlinear digital filter technique which is very widely used to eliminate noise from digital signals. It works by moving through the signal entry by entry, replacing each entry with the median of neighboring entries. The pattern of neighbors is called the “window,” which slides, entry by entry, over the entire signal [27]. The window size is the key step of the median filter design. In general, the larger the window is, the lower the frequency of the fitted signal is.

Through the simulation and measurement experiments, the high-frequency noise can be suppressed effectively when the window size is from 9 to 12 samples under the sampling frequency of 128 Hz; the low-frequency noise introduced mainly by respiration and movement can be reduced better when the window size is from 96 to 110.

In this application, the window size of the first median filter, , was set as 10 samples, corresponding approximately to 78 ms; that of the second median filter, , was set as 100 samples, corresponding approximately to 780 ms. The diagram of the denoising method is shown in Figure 3.

The main steps of the method are shown as follows.

The raw signal after normalization is denoted as . In order to prevent the boundary distortion, we used the boundary extension to process . The extension length is related to the size of the window; here we chose , and the signal after extension is recorded as , shown in

The first median filter with the window size was used to eliminate the high-frequency noise from ; then the signal after the processing is recorded as , and the value of equals the one from the sequence whose value corresponds to the minimum of the expression , where , .

The second median filter with the window size could be used to estimate the low-frequency noise of which is recorded as ; then the value of equals the one from the sequence whose value corresponds to the minimum of the expression , where , .

The denoised signal can be obtained by subtracting from , as shown in

3. Results and Discussion

3.1. The Experiment for Measured Signals

In the measurement experiment, the above two devices were used to collect multiple sets of transmitted and reflected PPG signals, of which the 10 subjects were under the calmly sitting and slightly moving postures. For convenient comparison, we continued to use the signals in Figure 2 to represent the denoising results.

The red curves in Figure 4 are the noise suppressed by using our proposed method. Figure 4(a) is the raw transmitted PPG signal (blue curve) under the sitting posture, named as TPPGS, and Figure 4(b) is that under the slightly moving posture, named as TPPGM; their corresponding denoised signals are shown, respectively, in Figure 4(c), named as DTPPGS, and in Figure 4(d), named as DTPPGM.

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(b)

(c)

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(e)

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(h)

Figure 4(e) is the raw reflected PPG signal (blue curve) under the sitting posture, named as RPPGS, and Figure 4(f) is that under the slightly moving posture, named as RPPGM; their corresponding denoised signals are shown in Figure 4(g), named as DRPPGS, and in Figure 4(h), named as DRPPGM.

From visual comparison of the morphology and the smoothness of the signals before and after denoising, the noise is well suppressed, and the quality of the PPG signals is improved by the denoising method.

For quantitative evaluation of the method, we performed spectral analysis of the PPG signals from Figure 4. The frequency of the major component of PPG signal is generally concentrated in 0.5-10 Hz; hence, the frequency values plotted in Figure 5 are set from 0 to 30 Hz for convenient observation. Figures 5(a)–5(h) correspond to the spectra of TPPGS, of DTPPGS, of TPPGM, of DTPPGM, of RPPGS, of DRPPGS, of RPPGM, and of DRPPGM, respectively. It can be found that the high frequency near 25 Hz and the low frequency near 0.5 Hz are well eliminated.

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(b)

(c)

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(e)

(f)

(g)

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3.2. The Experiment for Simulated Signals

We compared the denoising effects of the proposed method and a wavelet-based method. The wavelet-based method can remove baseline wander as well as partial motion artifacts effectively. However, it should be run on the host computer and it is not real-time. We used a fraction of good quality signals to be the reference signal. The noisy signals could be synthesized by adding simulated noise to the reference signal. Then, the two denoising methods were compared by using SNR.

We used 2000 representative samples from good quality reflected signals to be the reference signal, as shown in Figure 6(a). The simulated noise for baseline wander and partial motion artifacts is shown in Figure 6(b). The simulated noise being superposed on the reference signal synthesized a noisy signal, which is shown in Figure 6(c). We continue to add 10 dB white Gaussian noise to synthesize another noisy signal which contains not only the baseline wander and partial motion artifacts, but also the random noise, as shown in Figure 6(d). After using the wavelet-based method (please see [11, 12] for details), the denoised signal of Figure 6(c) is shown in Figure 6(e), and that of Figure 6(d) is shown in Figure 6(f). After using our proposed method, the denoised signal of Figure 6(c) is shown in Figure 6(g), and that of Figure 6(d) is shown in Figure 6(h).

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(b)

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Figure 6

Comparisons of the proposed method with the wavelet-based method. (a) The reference signal, (b) the simulated noise for baseline wander and partial motion artifacts, (c) the simulated noisy signal with baseline wander and partial motion noise, (d) the simulated noisy signal with multinoise, (e) the denoised signal of Figure 6(c) by using the wavelet-based method, (f) the denoised signal of Figure 6(d) by using the wavelet-based method, (g) the denoised signal of Figure 6(c) by using the proposed method, and (h) the denoised signal of Figure 6(d) by using the wavelet-based method.

The corresponding SNRs of the signals from Figure 6 were calculated. The comparison results are listed in Table 2.

The SNR calculated by using the noisy signal in Figure 6(c) is 7.6857 and those using the denoised signals in Figures 6(e) and 6(g) are 16.2620 and 12.7598, respectively; the SNR calculated by using the noisy signal in Figure 6(d) is 5.7739 and those using the denoised signals in Figures 6(f) and 6(h) are 6.1874 and 11.3860, respectively.

By comparing the morphology in Figure 6 and the SNR in Table 2, we can see that the quality of the signal is improved after denoising. Comparing Figures 6(c), 6(e), and 6(g), the noise is reduced well. Although the denoised effect by the wavelet-based method (SNR is 16.2620) is better than that by the proposed method (SNR is 12.7598), the wavelet-based method needs to run on the host computer and is not real-time. Comparing Figures 6(d), 6(f), and 6(h), the wavelet-based method is good at reducing that kind of low-frequency noise, but not the random noise, and the denoised effect of the proposed method (SNR is 11.3860) is much better than that by the wavelet-based method (SNR is 6.1874).

3.3. The Experiment for Strong Noisy Signals

During the experiment, it happened to start a suction electromagnetic vibrator that greatly increased the environmental noise in the measurement. At that time, we collected the raw signal by using the reflective oximeter. The representative 2000 samples are shown in Figure 7(a). Figure 7(b) is the spectrum of the raw signal, and the noise is severe in the signal. Figure 7(c) is the denoised signal using the method based on double median filters, and Figure 7(d) is the spectrum of the denoised signal. By comparing the morphology and spectrum of the signal before and after denoising, the validity of the denoising method is further verified.

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(b)

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The above denoising experiments used measured signals, simulated signals, and the strong noisy signals. By comparing the morphology, frequency spectrum, and SNR of the signals before and after denoising, the results demonstrated the effectiveness and practicability of the proposed method.

4. Conclusion

In this study, a simple, real-time PPG denoising method based on double median filters was proposed, which could be integrated in microcontroller of commercial or portable pulse oximeters without adding extra hardware. The experiments were conducted using measured signals, simulated signals, and the noisy signals collected under the strong noise environment. Through evaluating the denoising effects (morphology, frequency spectrum, and SNR comparisons of the signals), the experimental results showed that the proposed method can remove the noise well and enhance the quality of PPG signals. The proposed method has the potential to improve the calculation accuracy of the subsequent physiological parameters and can be a convenient solution to the real-time noise suppression for portable pulse oximeters as well. For future research, we will collect more PPG signals from volunteers to compare the noise reduction effects through the calculation accuracies of physiological parameters (such as HR and SpO₂) before and after denoising using the proposed method and traditional methods. And then, results will further reveal the feasibility and possibility of embedding the proposed method into commercial portable pulse oximeters.

Abbreviations

PPG:	Photoplethysmography
SpO₂:	Noninvasive blood oxygen saturation
MA:	Motion artifact
EMD:	Empirical mode decomposition
ICA:	Independent component analysis
SVD:	Singular value decomposition
BMI:	Body mass index
SNR:	Signal-to-noise ratio
TPPGS:	Transmitted PPG signal
DTPPGS:	Denoised transmitted PPG signal
TPPGM:	Transmitted PPG signal under moving
DTPPGM:	Denoised transmitted PPG signal under moving
RPPGS:	Reflected PPG signal
DRPPGS:	Denoised reflected PPG signal
RPPGM:	Reflected PPG signal under moving
DRPPGM:	Denoised reflected PPG signal under moving.

Data Availability

The data used to support the findings of this study are available from the corresponding author upon request.

Ethical Approval

We had received ethical approval from Jilin University to conduct the experiments.

The measurements were noninvasive and without any risk on volunteers. All volunteers had signed an informed consent for participation in the measurements.

Conflicts of Interest

The authors declare that they have no competing interests.

Authors’ Contributions

Suyi Li conceived this study and drafted the paper; Suyi Li and Jiang Wu designed the real-time denoising method based on double median filters; Dongsheng Li, Lijia Liu, and Bingyi Tang carried out the experiment and proved the validity of the method; all authors contributed to the discussion of the work and approved the final paper.

Acknowledgments

This study was supported by the National Key Technologies R&D Program of China (No. 2017YFC0307700) and National Natural Science Foundation of Jilin Province, China (No. 20180101049JC). The authors thank the members of the projects committee for their help.

References

R. Sahni, “Noninvasive monitoring by photoplethysmography,” Clinics in Perinatology, vol. 39, no. 3, pp. 573–583, 2012.
View at: Publisher Site | Google Scholar
M. E. van Genderen, S. A. Bartels, A. Lima et al., “Peripheral Perfusion Index as an Early Predictor for Central Hypovolemia in Awake Healthy Volunteers,” Anesthesia & Analgesia, vol. 116, no. 2, pp. 351–356, 2013.
View at: Publisher Site | Google Scholar
G. Liu, X. Wei, S. Zhang, X. Shang, and J. Cai, “Visual evoked nerve cerebral oxygen characteristics analysis based on NIRS-EEG,” Optik - International Journal for Light and Electron Optics, vol. 160, pp. 168–175, 2018.
View at: Publisher Site | Google Scholar
E. D. Chan, M. M. Chan, and M. M. Chan, “Pulse oximetry: Understanding its basic principles facilitates appreciation of its limitations,” Respiratory Medicine, vol. 107, no. 6, pp. 789–799, 2013.
View at: Publisher Site | Google Scholar
B. Venema, N. Blanik, V. Blazek, H. Gehring, A. Opp, and S. Leonhardt, “Advances in reflective oxygen saturation monitoring with a novel in-ear sensor system: Results of a human hypoxia study,” IEEE Transactions on Biomedical Engineering, vol. 59, no. 7, pp. 2003–2010, 2012.
View at: Publisher Site | Google Scholar
J. Wannenburg and R. Malekian, “Body sensor network for mobile health monitoring, a diagnosis and anticipating system,” IEEE Sensors Journal, vol. 15, no. 12, pp. 6839–6852, 2015.
View at: Publisher Site | Google Scholar
T. Guo, Z. Cao, S. Lv, W. Shuai, and M. Yu, “Development of a reflective hypothenar pulse oximeter and its calibration in human hypoxia experiment,” Yi Qi Yi Biao Xue Bao/Chinese Journal of Scientific Instrument, vol. 35, no. 1, pp. 30–35, 2014.
View at: Google Scholar
M. Elgendi, “On the analysis of fingertip photoplethysmogram signals,” Current Cardiology Reviews, vol. 8, no. 1, pp. 14–25, 2012.
View at: Publisher Site | Google Scholar
Q.-B. Li and Q.-Y. Han, “The method of removing high-frequency noise in pulse wave signal in detecting oxygen saturation of human,” Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis, vol. 32, no. 9, pp. 2523–2527, 2012.
View at: Publisher Site | Google Scholar
P. V. Kasambe and S. S. Rathod, “VLSI Wavelet based denoising of PPG signal,” in Proceedings of International Conference on Advances in Computing, Communication and Control, ICAC3 2015, pp. 282–288, India, April 2015.
View at: Google Scholar
N. R. Shetty, N. H. Prasad, and N. Nalini, Emerging Research in Computing, Information, Communication and Applications, Springer Singapore, Singapore, 2016.
View at: Publisher Site
Suyi Li, Shanqing Jiang, Shan Jiang, Jiang Wu, Wenji Xiong, and Shu Diao, “A Hybrid Wavelet-Based Method for the Peak Detection of Photoplethysmography Signals,” Computational and Mathematical Methods in Medicine, vol. 2017, Article ID 9468503, 8 pages, 2017.
View at: Publisher Site | Google Scholar | MathSciNet
C. Fischer, B. Domer, T. Wibmer, and T. Penzel, “An Algorithm for Real-Time Pulse Waveform Segmentation and Artifact Detection in Photoplethysmograms,” IEEE Journal of Biomedical and Health Informatics, vol. 21, no. 2, pp. 372–381, 2017.
View at: Publisher Site | Google Scholar
B. Lee, J. Han, H. J. Baek, J. H. Shin, K. S. Park, and W. J. Yi, “Improved elimination of motion artifacts from a photoplethysmographic signal using a Kalman smoother with simultaneous accelerometry,” Physiological Measurement, vol. 31, no. 12, pp. 1585–1603, 2010.
View at: Publisher Site | Google Scholar
M.-Z. Poh, N. C. Swenson, and R. W. Picard, “Motion-tolerant magnetic earring sensor and wireless earpiece for wearable photoplethysmography,” IEEE Transactions on Information Technology in Biomedicine, vol. 14, no. 3, pp. 786–794, 2010.
View at: Publisher Site | Google Scholar
H. Han and J. Kim, “Artifacts in wearable photoplethysmographs during daily life motions and their reduction with least mean square based active noise cancellation method,” Computers in Biology and Medicine, vol. 42, no. 4, pp. 387–393, 2012.
View at: Publisher Site | Google Scholar
M. R. Ram, K. V. Madhav, E. H. Krishna, N. R. Komalla, and K. A. Reddy, “A novel approach for motion artifact reduction in PPG signals based on AS-LMS adaptive filter,” IEEE Transactions on Instrumentation and Measurement, vol. 61, no. 5, pp. 1445–1457, 2012.
View at: Publisher Site | Google Scholar
M. R. Ram, K. Sivani, and K. A. Reddy, “Utilization of adaptive-coefficient estimation method for Motion artifacts reduction from photoplethysmographic signals,” in Proceedings of the 2016 IEEE International Conference on Wireless Communications, Signal Processing and Networking, WiSPNET 2016, pp. 818–822, India, March 2016.
View at: Google Scholar
M. Raghuram, K. V. Madhav, E. H. Krishna, N. R. Komalla, K. Sivani, and K. A. Reddy, “Dual-tree complex wavelet transform for motion artifact reduction of PPG signals,” in Proceedings of the 2012 IEEE International Symposium on Medical Measurements and Applications (MeMeA), pp. 1–4, Budapest, Hungary, May 2012.
View at: Publisher Site | Google Scholar
M. Raghu Ram, K. Sivani, and K. Ashoka Reddy, “Reduction of motion artifacts from pulse oximeter signals using tunable Q-factor wavelet transform technique,” in Proceedings of the 2017 International Conference on Computer, Communication, and Signal Processing, ICCCSP 2017, India, January 2017.
View at: Google Scholar
S. Mushrif and A. Morales, “A modified ICA framework for motion artifact removal in wrist-type photoplethysmography during exercise,” in Proceedings of the 20th IEEE International Symposium on Consumer Electronics, ISCE 2016, pp. 113-114, Brazil, September 2016.
View at: Google Scholar
F. Peng, Z. Zhang, X. Gou, H. Liu, and W. Wang, “Motion artifact removal from photoplethysmographic signals by combining temporally constrained independent component analysis and adaptive filter,” Biomedical Engineering Online, vol. 13, no. 1, article no. 50, 2014.
View at: Publisher Site | Google Scholar
A. Baca, G. Biagetti, M. Camilletti et al., “CARMA: A robust motion artifact reduction algorithm for heart rate monitoring from PPG signals,” in Proceedings of the 23rd European Signal Processing Conference, EUSIPCO 2015, pp. 2646–2650, France, September 2015.
View at: Google Scholar
M. Malekmohammadi and A. Moein, “A Brief Comparison of Adaptive Noise Cancellation, Wavelet and Cycle-by-Cycle Fourier Series Analysis for Reduction of Motional Artifacts from PPG Signals,” in 26th Southern Biomedical Engineering Conference SBEC 2010, April 30 - May 2, 2010, College Park, Maryland, USA, vol. 32 of IFMBE Proceedings, pp. 243–246, Springer Berlin Heidelberg, Berlin, Heidelberg, 2010.
View at: Publisher Site | Google Scholar
K. A. Reddy, B. George, and V. J. Kumar, “Use of Fourier series analysis for motion artifact reduction and data compression of photoplethysmographic signals,” IEEE Transactions on Instrumentation and Measurement, vol. 58, no. 5, pp. 1706–1711, 2009.
View at: Publisher Site | Google Scholar
R. Krishnan, B. Natarajan, and S. Warren, “Two-stage approach for detection and reduction of motion artifacts in photoplethysmographic data,” IEEE Transactions on Biomedical Engineering, vol. 57, no. 8, pp. 1867–1876, 2010.
View at: Publisher Site | Google Scholar
X. Cao, Y. Li, Y. Zhan et al., “Removing Noises Induced by Gamma Radiation in Cerenkov Luminescence Imaging Using a Temporal Median Filter,” BioMed Research International, vol. 2016, 2016.
View at: Google Scholar

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Copyright © 2018 Suyi Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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