|
| Number | Uniprot
accession | Protein name | Skin-associated functions | Fold change |
|
| (1) | P20591 | MX dynamin like GTPase 1 | Epidermal defense against viruses | 2.9 |
| (2) | P11117 | Acid phosphatase 2 | Skin homeostasis | 2.5 |
| (3) | Q03405 | Plasminogen activator, urokinase receptor | Migration of epidermal keratinocytes and outer root sheath cells during human morphogenesis | 2.2 |
| (4) | P25815 | S100 calcium binding protein P | Tumor growth, invasion and metastasis | 2 |
| (5) | Q460N5 | Poly(ADP-ribose) polymerase family member 14 | Cytokine production in allergic inflammation models | 1.8 |
| (6) | Q7Z4W1 | Dicarbonyl and L-xylulose reductase | Cell adhesion in normal keratinocytes, melanocytes and endothelial cells | 1.8 |
| (7) | Q9NVV5 | Androgen induced 1 | Involved in androgen-regulated hair cycle | 1.8 |
| (8) | P27701 | CD82 molecule | Suppress melanoma cell migration and invasion | 1.8 |
| (9) | A0A024RB23 | Diacylglycerol kinase alpha | Diacylglycerol-mediated lipid homeostasis and profibrotic fibroblast activation | 1.8 |
| (10) | O95471 | Claudin 7 | Epidermal neoplastic process | 1.7 |
| (11) | Q53FA7 | Tumor protein p53 inducible protein 3 | P53-regulated proapoptosis | 1.7 |
| (12) | X6R8F3 | Lipocalin 2 | Regulate growth, differentiation and migration of squamous cell carcinoma | 1.7 |
| (13) | Q9Y3Z3 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Limit HIV-1 infection in macrophages and regulate cell cycle progression in fibroblasts | 1.6 |
| (14) | B0QYD3 | Apolipoprotein B mRNA editing enzyme catalytic subunit 3B | Induce somatic mutations and involve in pathomechanism of several cancers (melanoma) | 1.6 |
| (15) | Q00978 | Interferon regulatory factor 9 | Inflammation | 1.6 |
| (16) | P05161 | ISG15 ubiquitin-like modifier | Regulate expression of pro-inflammatory chemokines and cytokines | 1.6 |
| (17) | P82673 | Mitochondrial ribosomal protein S35 | Activate inflammatory signaling | 1.6 |
| (18) | P09914 | Interferon induced protein with tetratricopeptide repeats 1 | Immunomodulation and interferon response | 1.6 |
| (19) | E7ESA6 | Protein tyrosine kinase 2 | Keratinocyte migration | 1.6 |
| (20) | A0A0A0MT64 | Ferredoxin reductase | Epidermal differentiation | 1.6 |
| (21) | A0A024R9E4 | Mal, T-cell differentiation protein 2 | May induce malignant mouse skin squamous cell carcinomas | 1.6 |
| (22) | P13645 | Keratin 10 | Keratinization-associated keratin, sebocyte proliferation and differentiation | −3.8 |
| (23) | P31151 | S100 calcium binding protein A7 | Epithelial inflammation | −2.5 |
| (24) | Q9Y5K6 | CD2 associated protein | Expression of plasmacytoid dendritic cells in dermis | −2.4 |
| (25) | P08240 | SRP receptor alpha subunit | Regulate keratinocyte proliferation by affecting cell cycle progression | −2.2 |
| (26) | P08779 | Keratin 16 | Associated with epidermal hyperproliferation | −1.9 |
| (27) | P02533 | Keratin 14 | Major keratin of basal keratinocytes | −1.9 |
| (28) | P29034 | S100 calcium binding protein A2 | Keratinocyte differentiation and carcinogenesis | −1.8 |
| (29) | P02760 | Alpha-1-microglobulin/bikunin precursor | Related to apoptosis or antiproliferation and might have causal roles in psoriasis | −1.7 |
| (30) | Q9NS00 | Core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 | Immune responses of CD8+ T cells and skin allograft survival | −1.7 |
| (31) | P35908 | Keratin 2 | Keratinocyte differentiation | −1.7 |
| (32) | Q15582 | Transforming growth factor beta 1 | Promote proliferation in melanoma cells | −1.7 |
| (33) | P04040 | Catalase | Oxidative stress causes abnormal keratinocyte proliferation and differentiation | −1.7 |
| (34) | P02649 | Apolipoprotein E | Epidermal proliferation and differentiation | −1.6 |
| (35) | P04259 | Keratin 6B | Markers of epithelial cell differentiation | −1.6 |
| (36) | Q9Y4K0 | Lysyl oxidase like 2 | Inhibit keratinocyte differentiation, promote development of squamous cell carcinoma | −1.6 |
| (37) | P18074 | ERCC excision repair 2, TFIIH core complex helicase subunit | Important DNA repair molecule for initiating cutaneous melanoma | −1.6 |
| (38) | A0A0S2Z381 | Adenosine deaminase | Immune system development, cell proliferation and differentiation | −1.6 |
| (39) | Q92626 | Peroxidasin | Basement membrane integrity and homeostasis | −1.6 |
| (40) | Q14117 | Dihydropyrimidinase | Enriched in somatic mutations of melanoma | −1.6 |
| (41) | Q05209 | Protein tyrosine phosphatase, non-receptor type 12 | Related to invasiveness of melanoma cells | −1.6 |
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