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BioMed Research International
Volume 2018 (2018), Article ID 9158187, 10 pages
Research Article

Secondary Degeneration of Auditory Neurons after Topical Aminoglycoside Administration in a Gerbil Model

1College of Medicine, Dankook University, Beckman Laser Institute Korea, Cheonan, Republic of Korea
2Department of Otolaryngology-Head & Neck Surgery, College of Medicine, Dankook University, Cheonan, Republic of Korea
3Dankook University Hospital, Cheonan, Republic of Korea

Correspondence should be addressed to Jae Yun Jung

Received 13 October 2017; Revised 29 December 2017; Accepted 9 January 2018; Published 1 March 2018

Academic Editor: Yong-Ho Park

Copyright © 2018 Jae-Hun Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hair cells in the cochlea can be damaged by various causes. Damaged hair cells can lead to additional destruction of parts of the auditory afferent pathway sequentially, which is called secondary degeneration. Recently, researches regarding cochlear implants have been actively carried out for clinical purposes; secondary degeneration in animals is a much more practical model for identifying the prognosis of cochlear implants. However, an appropriate model for this research is not established yet. Thus, we developed a secondary degeneration model using an ototoxic drug. 35 gerbils were separated into four different groups and kanamycin was applied via various approaches. ABR was measured several times after drug administration. SGCs were also counted to identify any secondary degeneration. The results showed that outer and inner HCs were damaged in all kanamycin-treated groups. Twelve weeks after kanamycin treatment, the round window membrane injection group showed severe subject differences in hair cells and SGC damage, whereas the gelfoam group showed consistent and severe damage in hair cells and SGCs. In this study, we successfully induced secondary degeneration in hair cells in a gerbil model. This model can be used for various purposes in the hearing research area either for treatment or for preservation.