Transcription Factor IRF4 Dysfunction Affects the Immunosuppressive Function of Treg Cells in Patients with Primary Immune Thrombocytopenia

Figure 1

The ratio of Th17/Treg cells increased; the secretion of IL-10 of Tregs decreased in ITP patients. (a) Representative dot plots of Tregs (CD4⁺CD2Foxp3⁺Treg cells) in ITP and NC groups. (b) Representative dot plots of Th17 cells (CD4⁺ IL-17⁺ cells) in ITP and NC groups. (c) The percentage of Treg cells in CD4⁺ T cells of ITP and NC groups. (d) The percentage of Th17 cells in CD4⁺T cells of ITP and NC groups. (e) The ratio of Th17/Treg in ITP and NC groups. (f) The expression of IL-10mRNA of Tregs in ITP and NC groups. NC: normal control; ITP: ITP group; p < 0. 05; p < 0. 01; p < 0. 001.

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