Transcription Factor IRF4 Dysfunction Affects the Immunosuppressive Function of Treg Cells in Patients with Primary Immune Thrombocytopenia

Figure 3

The target gene IL-10 of IRF4 was associated with the inhibition function of Treg cells in ITP patients. (a) IRF4 binding used by different primers of IL-10 promoter of CD4⁺CD2Foxp3⁺Treg cells, and CD4⁺CD25^-Teff cells in ITP and NC groups. (b) The specific location of IRF4 binding to 5 different IL-10 primers. (c) The intensity of IRF4 binding to IL-10 DNA on Tregs in ITP and NC groups. (d) The intensity of IRF4 binding to IL-10 DNA on Teffs in ITP and NC groups. (e) The intensity of IRF4 binding to IL-10 DNA on Tregs and Teffs in ITP and NC groups. NC: normal control, ITP: ITP group. p < 0. 05; p < 0. 01.

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