Potential Relationship between Clinical Significance and Serum Exosomal miRNAs in Patients with Multiple Myeloma

Table 3

Clinical features of multiple myeloma patients and the expression of exosomal miRNAs in different groups.

Characteristics	N (%)	let-7c-5p		let-7d-5p		miR-140-3p		miR-185-5p		miR-425-5p
	(n = 48)	Mean ± SD		Mean ± SD		Mean ± SD		Mean ± SD		Mean ± SD
Age			0.487		0.616		0.756		0.321		0.435
≥65	15 (31%)	1.32 ± 0.91		1.22 ± 1.11		1.09 ± 1.04		1.56 ± 2.01		1.94 ± 1.11
<65	33 (69%)	1.12 ± 0.84		1.06 ± 0.99		1.08 ± 0.96		0.98 ± 0.91		1.69 ± 0.58
Sex			0.456		0.605		0.169		0.956		0.404
Male	22 (46%)	1.32 ± 1.01		1.23 ± 1.22		0.86 ± 0.91		1.34 ± 1.73		0.67 ± 0.67
Female	26 (54%)	1.06 ± 0.71		1.00 ± 0.82		1.15 ± 1.02		0.99 ± 0.92		0.86 ± 0.86
Heavy chain			0.479		0.505		0.266		0.501		0.101
No expression	15 (31%)	1.02 ± 0.62		1.29 ± 0.67		1.03 ± 0.66		0.81 ± 0.72		0.59 ± 0.67
IgG	16 (34%)	1.27 ± 0.87		1.29 ± 1.23		1.04 ± 0.68		1.11 ± 0.88		0.66 ± 0.39
IgA	13 (27%)	1.37 ± 0.95		1.16 ± 1.12		1.34 ± 1.38		1.81 ± 2.21		1.26 ± 1.14
IgD	4 (8%)	0.83 ± 0.48		0.83 ± 0.47		0.50 ± 0.45		0.64 ± 0.86		0.46 ± 0.64
Light chain			0.805		0.846		0.366		0.568		0.595
Nonsecretion	1 (2%)	—		—		—		—		—
Κ	27 (56%)		1.10 ± 0.72		0.97 ± 0.68		0.96 ± 0.68		0.96 ± 0.75		0.75 ± 0.75
Λ	20 (42%)	1.24 ± 1.02		1.26 ± 0.1.36		0.99 ± 1.21		1.36 ± 0.1.81		0.73 ± 0.74
D-S stage			0.840		0.852		0.444		0.940		0.882
I	7 (15%)	1.19 ± 0.79		1.06 ± 0.74		0.93 ± 0.63		0.83 ± 0.67		1.10 ± 1.30
II	2 (4%)	1.11 ± 0.07		0.89 ± 0.03		1.31 ± 0.00		0.79 ± 0.25		0.60 ± 0.19
III	39 (81%)	1.19 ± 0.90		1.13 ± 1.09		1.02 ± 1.05		1.12 ± 1.45		0.78 ± 0.68
ISS stage			0.047		0.055		0.083		0.072		0.027
I	7 (15%)	1.91 ± 0.92		1.69 ± 0.79		1.61 ± 1.00		1.55 ± 1.02		1.63 ± 1.25
II	11 (23%)	1.03 ± 0.76		0.92 ± 0.75		0.81 ± 0.58		1.43 ± 0.98		0.67 ± 0.47
III	30 (62%)	1.07 ± 0.82		1.04 ± 1.12		0.94 ± 1.05		0.98 ± 1.43		0.60 ± 0.60
Renal damage			0.066		0.011		0.002		0.026		0.010
Yes	12 (25%)	0.79 ± 0.74		0.64 ± 0.49		0.28 ± 0.27		0.37 ± 0.42		0.26 ± 0.19
No	36 (75%)	1.32 ± 0.86		1.27 ± 0.1.10		1.27 ± 1.00		1.40 ± 1.45		0.93 ± 0.84

ISS, International Staging System; .