Potential Relationship between Clinical Significance and Serum Exosomal miRNAs in Patients with Multiple Myeloma

Table 4

Correlation between the expression of miRNA and different clinical characteristics.

Characteristics	let-7c-5p		let-7d-5p		miR-140-3p		miR-185-5p		miR-425-5p
	r		r		r		r		r
Hemoglobin	0.107	0.469	0.222	0.129	0.306	0.034	0.325	0.027	0.279	0.058
Neutrophil	0.038	0.802	0.020	0.892	−0.077	0.609	0.044	0.773	0.000	0.998
Platelet	0.115	0.440	0.106	0.477	0.256	0.083	0.259	0.086	0.296	0.046
Creatinine	−0.309	0.033	−0.227	0.120	−0.527	0.000	−0.500	0.000	−0.524	0.000
Ca	−0.140	0.341	−0.076	0.608	0.034	0.821	−0.013	0.930	0.076	0.609
β2-Microglobulin	−0.311	0.031	−0.412	0.004	−0.437	0.002	−0.483	0.001	−0.453	0.001
ALP	−0.097	0.513	−0.088	0.551	0.096	0.515	0.078	0.606	0.044	0.771
LDH	−0.032	0.828	0.017	0.907	−0.201	0.172	−0.140	0.354	−0.197	0.185
VEGF	−0.001	0.996	−0.147	0.377	−0.106	0.526	−0.152	0.370	−0.105	0.529
IL-6	−0.426	0.009	−0.244	0.146	−0.393	0.016	−0.420	0.011	−0.518	0.001
IL-6R	−0.206	0.215	−0.091	0.585	−0.038	0.823	−0.026	0.877	−0.096	0.568
TRAP5B	−0.070	0.681	0.075	0.661	−0.057	0.738	0.038	0.828	0.022	0.897
β-CTX	−0.326	0.047	−0.334	0.044	−0.346	0.036	−0.349	0.037	−0.415	0.011
25-OH-VD	0.124	0.465	0.128	0.450	0.177	0.296	0.248	0.144	0.237	0.158
BAP	0.010	0.954	0.075	0.660	−0.058	0.731	0.058	0.737	0.090	0.596
BM PC (%)	−0.311	0.031	−0.412	0.004	−0.437	0.002	−0.483	0.001	−0.453	0.001

; ; r, correlation; IL-6, interleukin-6; ALP, alkaline phosphatase; LDH, lactate dehydrogenase; VEGF, vascular endothelial growth factor; IL-6R, interleukin-6 receptor; TRAP5B, tartrate-resistant acid phosphatase; β-CTX, Β-type I collagen carboxy-terminal peptide; 25-OH-VD, 25-hydroxyvitamin D; BAP, bone alkaline phosphatase; BM PC, bone marrow plasma cells.