Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2019, Article ID 1759697, 14 pages
https://doi.org/10.1155/2019/1759697
Research Article

Expression Profiling of Exosomal miRNAs Derived from the Peripheral Blood of Kidney Recipients with DGF Using High-Throughput Sequencing

1Department of Urology, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou 450003, China
2Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China

Correspondence should be addressed to Tianzhong Yan; moc.liamtoh@064zty

Received 27 February 2019; Revised 13 May 2019; Accepted 23 May 2019; Published 12 June 2019

Guest Editor: Johnathan Collett

Copyright © 2019 Junpeng Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. G. Yarlagadda, S. G. Coca, R. N. Formica, E. D. Poggio, and C. R. Parikh, “Association between delayed graft function and allograft and patient survival: a systematic review and meta-analysis,” Nephrology Dialysis Transplantation , vol. 24, no. 3, pp. 1039–1047, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. B. Schröppel and C. Legendre, “Delayed kidney graft function: from mechanism to translation,” Kidney International, vol. 86, no. 2, pp. 251–258, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. S. N. Tapiawala, K. J. Tinckam, C. J. Cardella et al., “Delayed graft function and the risk for death with a functioning graft,” Journal of the American Society of Nephrology, vol. 21, no. 1, pp. 153–161, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Sharif and R. Borrows, “Delayed graft function after kidney transplantation: the clinical perspective,” American Journal of Kidney Diseases, vol. 62, no. 1, pp. 150–158, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Keller, M. P. Sanderson, A. Stoeck, and P. Altevogt, “Exosomes: from biogenesis and secretion to biological function,” Immunology Letters, vol. 107, no. 2, pp. 102–108, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. E. van der Pol, A. N. Böing, P. Harrison, A. Sturk, and R. Nieuwland, “Classification, functions, and clinical relevance of extracellular vesicles,” Pharmacological Reviews, vol. 64, no. 3, pp. 676–705, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Mirzakhani, M. Mohammadnia-Afrouzi, M. Shahbazi, S. A. Mirhosseini, H. M. Hosseini, and J. Amani, “The exosome as a novel predictive/diagnostic biomarker of rejection in the field of transplantation,” Clinical Immunology, vol. 203, pp. 134–141, 2019. View at Publisher · View at Google Scholar
  8. C. Thery, KW. Witwer, E. Aikawa et al., “Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the international society for extracellular vesicles and update of the MISEV2014 guidelines,” Journal of Extracellular Vesicles, vol. 7, Article ID 1535750, 2018. View at Google Scholar
  9. H. Valadi, K. Ekström, A. Bossios, M. Sjöstrand, J. J. Lee, and J. O. Lötvall, “Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells,” Nature Cell Biology, vol. 9, no. 6, pp. 654–659, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. B. K. Thakur, H. Zhang, A. Becker et al., “Double-stranded DNA in exosomes: a novel biomarker in cancer detection,” Cell Research, vol. 24, no. 6, pp. 766–769, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. N. P. Hessvik and A. Llorente, “Current knowledge on exosome biogenesis and release,” Cellular and Molecular Life Sciences, vol. 75, no. 2, pp. 193–208, 2018. View at Publisher · View at Google Scholar · View at Scopus
  12. B. Dhondt, J. Van Deun, S. Vermaerke et al., “Urinary extracellular vesicle biomarkers in urological cancers: from discovery towards clinical implementation,” The International Journal of Biochemistry & Cell Biology, vol. 99, pp. 236–256, 2018. View at Publisher · View at Google Scholar · View at Scopus
  13. B. Yang, Y. Chen, and J. Shi, “Exosome biochemistry and advanced nanotechnology for next-generation theranostic platforms,” Advanced Materials, vol. 31, no. 2, Article ID e1802896, 2019. View at Publisher · View at Google Scholar
  14. S. Roy, F. H. Hochberg, and P. S. Jones, “Extracellular vesicles: the growth as diagnostics and therapeutics; a survey,” Journal of Extracellular Vesicles (JEV), vol. 7, no. 1, Article ID 1438720, 2018. View at Publisher · View at Google Scholar
  15. X. Yu, C. Huang, B. Song et al., “CD4+CD25+ regulatory T cells-derived exosomes prolonged kidney allograft survival in a rat model,” Cellular Immunology, vol. 285, no. 1-2, pp. 62–68, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. I. S. Dewi, S. Celik, A. Karlsson et al., “Exosomal miR-142-3p is increased during cardiac allograft rejection and augments vascular permeability through down-regulation of endothelial RAB11FIP2 expression,” Cardiovascular Research, vol. 113, no. 5, pp. 440–452, 2017. View at Google Scholar · View at Scopus
  17. H. Zhang, E. Huang, J. Kahwaji et al., “Plasma exosomes from HLA-sensitized kidney transplant recipients contain mrNA transcripts which predict development of antibody-mediated rejection,” Transplantation, vol. 101, no. 10, pp. 2419–2428, 2017. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Lim, C. Lee, K. Y. Kim et al., “Novel urinary exosomal biomarkers of acute T cell-mediated rejection in kidney transplant recipients: a cross-sectional study,” PLoS ONE, vol. 13, no. 9, Article ID e0204204, 2018. View at Publisher · View at Google Scholar
  19. A. Kainz, J. Wilflingseder, C. Mitterbauer et al., “Steroid pretreatment of organ donors to prevent postischemic renal allograft failure: a randomized, controlled trial,” Annals of Internal Medicine, vol. 153, no. 4, pp. 222–230, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Mengel, B. Sis, M. Haas et al., “Banff 2011 meeting report: new concepts in antibody-mediated rejection,” American Journal of Transplantation, vol. 12, no. 3, pp. 563–570, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Maragkakis, P. Alexiou, G. L. Papadopoulos et al., “Accurate microRNA target prediction correlates with protein repression levels,” BMC Bioinformatics, vol. 10, article 1471, p. 295, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. K. C. Miranda, T. Huynh, and Y. Tay, “A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes,” Cell, vol. 126, no. 6, pp. 1203–1217, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. D. W. Huang, B. T. Sherman, and R. A. Lempicki, “Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources,” Nature Protocols, vol. 4, no. 1, pp. 44–57, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. J. Liao, R. Liu, L. Yin, and Y. Pu, “Expression profiling of exosomal miRNAs derived from human esophageal cancer cells by Solexa high-throughput sequencing,” International Journal of Molecular Sciences, vol. 15, no. 9, pp. 15530–15551, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. H. Lu, X. Ning, Y. Chen et al., “Predictive value of serum creatinine, blood urea nitrogen, uric acid, and β2-microglobulin in the evaluation of acute kidney injury after orthotopic liver transplantation,” Chinese Medical Journal, vol. 131, no. 9, pp. 1059–1066, 2018. View at Publisher · View at Google Scholar
  26. E. C. Lorenz, Z. M. El-Zoghby, H. Amer et al., “Kidney allograft function and histology in recipients dying with a functioning graft,” American Journal of Transplantation, vol. 14, no. 7, pp. 1612–1618, 2014. View at Publisher · View at Google Scholar · View at Scopus
  27. C. Stambe, R. C. Atkins, G. H. Tesch, T. Masaki, G. F. Schreiner, and D. J. Nikolic-Paterson, “The role of p38α mitogen-activated protein kinase activation in renal fibrosis,” Journal of the American Society of Nephrology, vol. 15, no. 2, pp. 370–379, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. J. Li, N. V. Campanale, R. J. Liang, J. A. Deane, J. F. Bertram, and S. D. Ricardo, “Inhibition of p38 mitogen-activated protein kinase and transforming growth factor-β1/smad signaling pathways modulates the development of fibrosis in adriamycin-induced nephropathy,” The American Journal of Pathology, vol. 169, no. 5, pp. 1527–1540, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. Z. Xu, C. Zhao, Z. Wang et al., “Interleukin-33 levels are elevated in chronic allograft dysfunction of kidney transplant recipients and promotes epithelial to mesenchymal transition of human kidney (HK-2) cells,” Gene, vol. 644, pp. 113–121, 2018. View at Google Scholar · View at Scopus
  30. R. Y. Yan, S. J. Wang, G. T. Yao, and Z. G. Liu, “he protective effect and its mechanism of 3-n-butylphthalide pretreatment on cerebral ischemia reperfusion injury in rats,” European Review for Medical and Pharmacological Sciences, vol. 21, pp. 5275–5282, 2017. View at Google Scholar
  31. S. I. Khan, R. K. Malhotra, N. Rani et al., “Febuxostat modulates MAPK/NF-κBp65/TNF-α signaling in cardiac ischemia-reperfusion injury,” Oxidative Medicine and Cellular Longevity, vol. 2017, Article ID 8095825, 13 pages, 2017. View at Publisher · View at Google Scholar
  32. F. Ulbrich, K. B. Kaufmann, A. Meske et al., “The CORM ALF-186 mediates anti-apoptotic signaling via an activation of the p38 MAPK after ischemia and reperfusion injury in retinal ganglion cells,” PLoS ONE, vol. 11, no. 10, Article ID e0165182, 2016. View at Google Scholar · View at Scopus
  33. J. Wilflingseder, H. Regele, P. Perco et al., “MiRNA profiling discriminates types of rejection and injury in human renal allografts,” Transplantation, vol. 95, no. 6, pp. 835–841, 2013. View at Publisher · View at Google Scholar · View at Scopus
  34. Q. Chen, R. Zhou, Y. Zhang et al., “Bone marrow mesenchymal stromal cells attenuate liver allograft rejection may via upregulation PD-L1 expression through downregulation of miR-17-5p,” Transplant Immunology, vol. 51, pp. 21–29, 2018. View at Publisher · View at Google Scholar
  35. Z. Jafarzadeh-Samani, S. Sohrabi, K. Shirmohammadi, H. Effatpanah, R. Yadegarazari, and M. Saidijam, “Evaluation of miR-22 and miR-20a as diagnostic biomarkers for gastric cancer,” Chinese Clinical Oncology, vol. 6, no. 2, pp. 1–6, 2017. View at Publisher · View at Google Scholar · View at Scopus
  36. D. Huang, G. Bian, Y. Pan et al., “MiR-20a-5p promotes radio-resistance by targeting Rab27B in nasopharyngeal cancer cells,” Cancer Cell International, vol. 17, no. 1, p. 32, 2017. View at Google Scholar · View at Scopus