Clinical Features and Cytokine Profile in Myositis Patients with Anti-EJ Autoantibodies Detected by a Novel Immunoprecipitation Assay

Figure 3

Decline of anti-EJ levels in two patients during disease remission. (a) The anti-EJ antibody levels were detected using the established protein IP assay in four longitudinal sera from patient YWN at 0d, 6d, 20d, 150d after treatment and three longitudinal sera from patient M127 at 0d, 20d, 150d after treatment. (b) Images from HRCT of the Chest on Admission. Selected axial CT images from the upper (Panel A), middle (Panel B), and lower (Panel C) thorax show bilateral reticular opacity and area of confluence along the bronchovascular bundle, localized traction bronchiectasis (arrows), as well as diffused ground-glass opacity, with most severe involvement of both lower lobes (Panel D). (c) Follow-up HRCT images obtained 5 Months after Admission. Selected axial CT images from the upper (Panel A), middle (Panel B), and lower (Panel C) thorax at the same levels as in Figure 1 show a decrease in bilateral reticular opacities and ground-glass. A coronal reformation (Panel D) shows mild traction bronchiolectasis (arrow). These findings are consistent with improvement of interstitial lung disease.

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