Effects of Xingnaojing Injection on Adenosinergic Transmission and Orexin Signaling in Lateral Hypothalamus of Ethanol-Induced Coma Rats
Effect of XNJI on AD release in the LHA. (a-d) represents HPLC chromatograms of standard and AD at 135â€‰min after administration in control, EIC, and XNJI-M, respectively. Comparing the retention time and area under the peak to the AD standards, AD peak in the dialysates was identified and quantified. As compared to the area under the peak of control, that of EIC was increased. As compared to the EIC, the area under the peak of XNJI-M was decreased. (e-h) depict the hourly profile of AD level during the experiment. As compared to control animals, ethanol-treated rats displayed a significant increase in the LHA AD level. (P <0.05; LSD post hoc test; n=6). As compared to EIC, XNJI-M significantly decreased AD release in the LHA (P <0.05, LSD post hoc test). See text for details. # P <0.05 and ## P <0.01, versus the control group; P <0.05 and P <0.01, versus the EIC.
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