Effects of Xingnaojing Injection on Adenosinergic Transmission and Orexin Signaling in Lateral Hypothalamus of Ethanol-Induced Coma Rats
Effect of XNJI on the LHA OX1R, A1R, ENT1, and ADK gene expression following acute ethanol intake. (a-d) display the changes of OX1R, A1R, and ENT1 gene expression among five groups respectively. Acute ethanol exposure produced a significant decrease (P <0.05; LSD post hoc test; n=6) in OX1R expression coupled with an increase (P <0.01; LSD post hoc test) in A1R and ENT1 expression. However, unilateral injection of XNJI into the lateral ventricle blocked ethanol-induced downregulation of OX1R expression and upregulation of A1R and ENT1 expression. Furthermore, XNJI-H significantly upregulated ADK expression (P <0.01; LSD post hoc test). See text for details. # P <0.05 and ## P <0.01, versus the control group; P <0.05 and P <0.01, versus the EIC.
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