Genotypes and Hot Spot Mutations of Hepatitis B Virus in Northwest Chinese Population and Its Correlation with Diseases Progression

Table 1

Demographic and serological features of each group.

	HCC	Non-HCC	^1	Non-HCC		^1
				Treatment-naive	NA-resistant
n	433	547		494	53
Age^2	53.56 ± 11.27	52.24 ± 11.86	0.08	51.36 ± 12.03	50.21 ± 10.27	0.50
Gender ratio (male/female)	1.62	1.43	0.37	1.47	1.12	0.35
HBV DNA (IU/ml, log10)^3	2.72 (1.07, 4.92)	3.68 (3.04, 6.17)	<0.01	3.92 (2.41, 5.25)	3.61 (1.58, 5.46)	0.79
ALT (IU/L)^3	155.60 (43.10, 391.50)	79.50 (28.90, 326.70)	0.41	76.60 (31.50, 283.50)	62.00 (42.80, 254.50)	0.59
Genotype			<0.01			0.68
B	139 (32.10%)	220 (40.22%)	0.007	198 (40.08%)	22 (41.51%)
C	286 (66.05%)	315 (57.59%)		286 (57.89%)	29 (54.72%)
D	8 (1.85%)	12 (2.19%)		10 (2.02%)	2 (3.77%)
Subtype
HBV/B
B1	7 (5.04%)	14 (6.36%)	0.602	2 (1.01%)	0 (0.00%)	1.000
B2	132 (94.96%)	206 (93.64%)		196 (98.99%)	22 (100.00%)
HBV/C
C1	42 (14.69%)	52 (16.51%)	0.539	33 (11.54%)	6 (20.69%)	0.149
C2	244 (85.31%)	263 (83.49%)		253 (88.46%)	23 (79.31%)

¹Student’s t-test or Mann–Whitney U test was used for continuous data, and chi-square or Fisher’s exact test was used for categorical data. ²Data are shown as mean ± standard deviation. ³Data are shown as median (quartile 25, quartile 75).