Relationship between Serum Vitamin D and Calcium Levels and Vitamin D Receptor Gene Polymorphisms in Colorectal Cancer

Table 2

Correlation between different genotypes of ApaI SNP with the expression of total vitamin D, 25(OH)D₃, and calcium serum levels in patients and controls.

Biochemical test	Patients (n=50)			Controls (n=50)			P value
	Frequency ()			Frequency ()
	AA	Aa	aa	AA	Aa	aa
	22 (44%)	19 (38%)	9 (18%)	37 (74%)	8 (16%)	5 (10%)
Total vitamin D (nmol/L)	67.96±5.84	73.58±10.68	171.60±35.82	143.80±12.88	132.30±19.71	155.20±28.08	< 0.0001
P value	0.0071			0.86
25(OH)D3 (nmol/L)	27.95±2.19	37.63±3.05	36.44±6.70	37.68±2.06	33.13±5.28	44.60±11.06	0.12
P value	0.08			0.81
Calcium (mmol/L)	2.26±0.021	2.15±0.042	2.26±0.044	2.31±0.016	2.34±0.023	2.33±0.055	0.0007
P value	0.04			0.47

P value was calculated by Kruskal-Wallis test with Dunn’s multiple comparison.