Relationship between Serum Vitamin D and Calcium Levels and Vitamin D Receptor Gene Polymorphisms in Colorectal Cancer

Table 5

Correlation between different genotypes of FokI SNP with the expression of total vitamin D, 25(OH)D₃, and calcium serum levels in patients and controls.

Biochemical test	Patients (n=50)			Controls (n=50)			P value
	Frequency ()			Frequency ()
	FF	Ff	ff	FF	Ff	ff
	33 (66%)	13 (26%)	4 (8%)	24 (48%)	23 (46%)	3 (6%)
Total vitamin D (nmol/L)	91.62±13.49	79.15±11.75	91.89±26.26	154.0±16.46	136.20±14.21	109.0±11.36	0.0013
P value	0.87			0.57
25(OH)D3 (nmol/L)	33.00±2.69	32.69±3.00	36.00±6.88	42.83±2.62	33.48±2.98	28.00±9.02	0.06
P value	0.82			0.02
Calcium (mmol/L)	2.22±0.029	2.21±0.023	2.19±0.058	2.33±0.018	2.31±0.019	2.22±0.095	0.0012
P value	0.39			0.30

P value was calculated by Kruskal-Wallis test with Dunn’s multiple comparison.