BioMed Research International

BioMed Research International / 2019 / Article
Special Issue

Natural Compounds against Cancer, Inflammation, and Oxidative Stress

View this Special Issue

Editorial | Open Access

Volume 2019 |Article ID 9495628 |

Claudio Tabolacci, Cinzia Forni, Ravirajsinh N. Jadeja, Francesco Facchiano, "Natural Compounds against Cancer, Inflammation, and Oxidative Stress", BioMed Research International, vol. 2019, Article ID 9495628, 2 pages, 2019.

Natural Compounds against Cancer, Inflammation, and Oxidative Stress

Received24 Apr 2019
Accepted24 Apr 2019
Published09 May 2019

Natural products, compounds derived from animals, micro-organisms and, especially, from plants, have been used in prevention and treatment of various human diseases for thousands of years. Some of these bioactive compounds, which have beneficial effects on human health, are also present in foods and beverages. In recent years, the interest towards the use of natural compounds and their derivatives has been renewed, even for the discovery and development of new drugs [1].

Phytochemicals show positive effects on human health by a large variety of mechanisms, including epigenetic modifications, modulation of signal transduction and metabolic pathways, and regulation of antioxidant enzymes activity [2, 3]. This is the reason why they have been extensively studied for their anticancer activities, through the potential modulation of cancer initiation and growth, cellular differentiation, apoptosis and autophagy, angiogenesis, and metastatic dissemination. Moreover, several active herbal compounds are tested in human clinical trials, used as adjuvants with conventional anticancer therapies in order to reduce side effects like nausea and fatigue [4].

Further, phytochemicals are considered today potent and effective weapons against several human diseases, due to their mechanism of action that in many cases is against oxidative stress. In fact, a considerable number of studies reported the use of natural compounds for their anti-inflammatory activity, since inflammation is considered the basis of various disease conditions, including cancer. The use of herbal preparation in combination with suitable diet represents also one of the most promising strategies to treat metabolic disorders like diabetes, obesity, and metabolic syndrome [5]. Moreover, due to their several biological activities, natural compounds represent good candidates for preventing and even curing the effects of neurodegenerative diseases.

The aim of this Special Issue was to provide a contribution in collecting new findings in the use of natural products against cancer, inflammation, and oxidative stress. After a careful peer review process, twenty-one papers were accepted for publication in this Special Issue, including three review articles and one clinical study.

Conflicts of Interest

The Guest Editors report no conflicts of interest.


We are grateful to all authors for their important contribution to this Special Issue. We sincerely thank all reviewers for their fundamental efforts. We are also grateful to the Editorial Board of BioMed Research International for giving us the opportunity to take care of a Special Issue focused on a so important research field. Claudio Tabolacci was partially supported by Fondazione Umberto Veronesi.

Claudio Tabolacci
Cinzia Forni
Ravirajsinh N. Jadeja
Francesco Facchiano


  1. N. Thomford, D. Senthebane, A. Rowe et al., “Natural products for drug discovery in the 21st century: innovations for novel drug discovery,” International Journal of Molecular Sciences, vol. 19, no. 6, Article ID E1578, 2018. View at: Publisher Site | Google Scholar
  2. E. Ratovitski, “Anticancer natural compounds as epigenetic modulators of gene expression,” Current Genomics, vol. 18, no. 2, pp. 175–205, 2017. View at: Publisher Site | Google Scholar
  3. P. Pratheeshkumar, C. Sreekala, Z. Zhang et al., “Cancer prevention with promising natural products: mechanisms of action and molecular targets,” Anti-Cancer Agents in Medicinal Chemistry, vol. 12, no. 10, pp. 1159–1184, 2012. View at: Publisher Site | Google Scholar
  4. T. Costea, A. Hudiță, O. Ciolac et al., “Chemoprevention of colorectal cancer by dietary compounds,” International Journal of Molecular Sciences, vol. 19, no. 12, Article ID E3787, 2018. View at: Publisher Site | Google Scholar
  5. L. Carrera-Quintanar, R. I. López Roa, S. Quintero-Fabián et al., “Phytochemicals that influence gut microbiota as prophylactics and for the treatment of obesity and inflammatory diseases,” Mediators of Inflammation, vol. 2018, Article ID 9734845, 18 pages, 2018. View at: Publisher Site | Google Scholar

Copyright © 2019 Claudio Tabolacci et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

More related articles

 PDF Download Citation Citation
 Download other formatsMore
 Order printed copiesOrder

Related articles

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.