BioMed Research International / 2020 / Article / Tab 5

Research Article

Association of EPAS1 and PPARA Gene Polymorphisms with High-Altitude Headache in Chinese Han Population

Table 5

Association between rs4953354, rs6756667, rs6520015, and HAH intensity.

SNPModelAllele/genotypenon-HAH [n (%)]Mild HAH [n (%)]Moderate-severe HAH [n (%)] valuea valueb

rs4953354AlleleA264 (83.0)595 (88.5)154 (90.6)0.0170.023
G54 (17.0)77 (11.5)16 (9.4)
DominantAA109 (68.6)262 (78.0)69 (81.2)0.0240.034
AG/GG50 (31.4)74 (22.0)16 (18.8)
RecessiveAA/AG155 (97.5)333 (99.1)85 (100.0)0.2190.301
GG4 (2.5)3 (0.9)0 (0.0)

rs6756667AlleleG270 (84.9)603 (89.7)155 (91.2)0.0280.049
A48 (15.1)69 (10.3)15 (8.8)
DominantGG115 (72.3)269 (80.1)70 (82.4)0.0540.081
AG/AA44 (27.7)67 (19.9)15 (17.6)
RecessiveGG/AG155 (97.5)334 (99.4)85 (100.0)0.0870.301
AA4 (2.5)2 (0.6)0 (0.0)

rs6520015AlleleT249 (78.3)565 (84.1)146 (85.9)0.0260.042
C69 (21.7)107 (15.9)24 (14.1)
DominantTT96 (60.4)241 (71.7)61 (71.8)0.0110.077
CT/CC63 (39.6)95 (28.3)24 (28.2)
RecessiveTT/CT153 (96.2)324 (96.4)85 (100.0)0.9110.095
CC6 (3.8)12 (3.6)0 (0.0)

Association between SNPs and HAH intensity was analyzed in allele-dose, under dominant and recessive model by using Chi-squared test (2 2 contingency table, df = 1). aMild HAH group vs. non-HAH group; bModerate-severe HAH group vs. non-HAH group. indicated statistical significance. See Table 3 for group abbreviations.