Association of EPAS1 and PPARA Gene Polymorphisms with High-Altitude Headache in Chinese Han Population
Table 5
Association between rs4953354, rs6756667, rs6520015, and HAH intensity.
SNP
Model
Allele/genotype
non-HAH [n (%)]
Mild HAH [n (%)]
Moderate-severe HAH [n (%)]
valuea
valueb
rs4953354
Allele
A
264 (83.0)
595 (88.5)
154 (90.6)
0.017
0.023
G
54 (17.0)
77 (11.5)
16 (9.4)
Dominant
AA
109 (68.6)
262 (78.0)
69 (81.2)
0.024
0.034
AG/GG
50 (31.4)
74 (22.0)
16 (18.8)
Recessive
AA/AG
155 (97.5)
333 (99.1)
85 (100.0)
0.219
0.301
GG
4 (2.5)
3 (0.9)
0 (0.0)
rs6756667
Allele
G
270 (84.9)
603 (89.7)
155 (91.2)
0.028
0.049
A
48 (15.1)
69 (10.3)
15 (8.8)
Dominant
GG
115 (72.3)
269 (80.1)
70 (82.4)
0.054
0.081
AG/AA
44 (27.7)
67 (19.9)
15 (17.6)
Recessive
GG/AG
155 (97.5)
334 (99.4)
85 (100.0)
0.087
0.301
AA
4 (2.5)
2 (0.6)
0 (0.0)
rs6520015
Allele
T
249 (78.3)
565 (84.1)
146 (85.9)
0.026
0.042
C
69 (21.7)
107 (15.9)
24 (14.1)
Dominant
TT
96 (60.4)
241 (71.7)
61 (71.8)
0.011
0.077
CT/CC
63 (39.6)
95 (28.3)
24 (28.2)
Recessive
TT/CT
153 (96.2)
324 (96.4)
85 (100.0)
0.911
0.095
CC
6 (3.8)
12 (3.6)
0 (0.0)
Association between SNPs and HAH intensity was analyzed in allele-dose, under dominant and recessive model by using Chi-squared test (2 2 contingency table, df = 1). aMild HAH group vs. non-HAH group; bModerate-severe HAH group vs. non-HAH group. indicated statistical significance. See Table 3 for group abbreviations.
