Association of EPAS1 and PPARA Gene Polymorphisms with High-Altitude Headache in Chinese Han Population

Table 7

Distribution of rs4953354 and rs6520015 in HAH and non-HAH groups.

Subgroups	HAH+ [n (%)]	HAH− [n (%)]	OR (95% CI)	value	OR (95% CI)^a	value^a
1	237 (56.29)	66 (41.51)	1		1
2	65 (15.44)	30 (18.87)	0.60 (0.36–1.01)	0.053	0.60 (0.35–1.02)	0.059
3	94 (22.33)	43 (27.04)	0.61 (0.39–0.96)	0.032	0.63 (0.40–0.99)	0.049
4	25 (5.94)	20 (12.58)	0.35 (0.18–0.67)	0.001	0.36 (0.18–0.70)	0.003

Subgroup 1: subjects carrying neither rs4953354 “AG/GG” nor rs6520015 “CT/CC”; subgroup 2: subjects carrying rs4953354 “AG/GG” but not rs6520015 “CT/CC”; subgroup 3: subjects carrying rs6520015 “CT/CC” but not rs4953354 “AG/GG”; subgroup 4: subjects carrying both rs4953354 “AG/GG” and rs6520015 “CT/CC”. ^aAdjusted for age, height, weight, BMI, smoking and drinking status, HR, SpO₂, SBP, and DBP. indicated statistical significance. HAH+, subjects with HAH; HAH−, subjects without HAH. See Table 3 for group abbreviations.