miR-876 Inhibits EMT and Liver Fibrosis via POSTN to Suppress Metastasis in Hepatocellular Carcinoma

Table 5

Univariate and multivariate survival analyses of the prognostic factors associated with survival in HCC patients ().

OS	Univariate analysis			Multivariate analyses
	Patients/	Mean survival time	value	HR	95% CI	value
Gender
Male/female	105/22	38/45	0.368
Age (years)
≥60/<60	25/102	38/45	0.698
Tumor size (cm)
≤5/>5	31/96	53/36	0.037			0.756
Tumor number
Single/multiple	93/34	39/47	0.494
HBsAg
Yes/no	111/16	43/44	0.303
AFP
>400/≤400	64/63	37/47	0.334	2.530	1.433-4.468	0.001
Liver cirrhosis
Yes/no	61/66	38/44	0.041			0.480
Child stage
A/B	118/9	44/28	0.489
Tumor thrombus
Yes/no	26/101	23/48	<0.001			0.205
Stage (UICC)
I-II/III-IV	78/49	50/30	0.001			0.386
miR-876 expression
Low/high	64/63	35/50	0.022			0.496
POSTN expression
Low/high	64/63	51/34	0.012	1.717	1.008-2.926	0.047