BioMed Research International has retracted the article titled “Lentivirus-Mediated siRNA Targeting ER-α Inhibits Tumorigenesis and Induces Apoptosis in Hepatocarcinoma Cells” [1] due to an error in the gene targeting.
It was raised to our attention [2] that the siRNA sequence said to target ER-α (estrogen receptor alpha), , instead targets the similarly named but unrelated gene ERAL1 (Era Like 12S Mitochondrial RRNA Chaperone 1) [3].
Over 300 words, including the discussion of the use of siRNA, overlap with an article by other authors that was not cited, which also studied lentivirus-mediated RNA inference in hepatocarcinoma cells [4]. The file properties show the manuscript was edited by someone who is not one of the authors. The authors could not be contacted.