Granulomatous Dermatitis and Systemic Disease: An Association to Consider

Figure 2

Histological picture in lesional skin samples. (a, f) Interstitial granulomatous dermatitis. Hypercellular “busy” dermis due to increased numbers of inflammatory cells, mainly represented by histiocytes and lymphocytes. They are arranged around vessels and between collagen bundles. A slight increased amount of interstitial mucin is noted in (f) ((a) original magnification ×5 and inset ×10, hematoxylin and eosin; (f) original magnification ×5 and inset ×20, hematoxylin and eosin). (b, e) Necrobiotic (collagenolytic) pattern of granuloma annulare. In the superficial and middermis, an area of necrobiosis is surrounded by a rim of peripheral histiocytes, lymphocytes, and variable numbers of multinucleate giant cells. A perivascular inflammatory infiltrate is also noted ((b) original magnification ×5 and inset ×20, hematoxylin and eosin; (e) original magnification ×5 and inset ×20, hematoxylin and eosin). (c, d) Interstitial pattern of granuloma annulare. Lymphohistiocytic inflammatory dermal infiltration among collagen fibers and mucin deposits ((c) original magnification ×5 and inset X20, hematoxylin and eosin; (d) original magnification ×5 and inset ×20, hematoxylin and eosin).

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