Protective Effects of MitoTEMPO on Nonalcoholic Fatty Liver Disease via Regulating Myeloid-Derived Suppressor Cells and Inflammation in Mice
Effects of MitoTEMPO on HFD-induced liver fibrosis. (a–c) The mRNA levels of α-SMA (a), Collagen-I (b), and TIMP1 (c) in the liver tissues of the lean, HFD, and HFD+Mito groups. mRNA levels were normalized to GAPDH expression and shown as fold change (2-ΔΔCt). (d) The protein expression of α-SMA in the liver tissues of each group. The bottom shows the relative band intensity of α-SMA to β-actin. Data represent the from three independent experiments. HFD vs. lean: , HFD+Mito vs. HFD: ##,###, unpaired -test.
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