IL-6 Promotes the Proliferation and Immunosuppressive Function of Myeloid-Derived Suppressor Cells via the MAPK Signaling Pathway in Bladder Cancer

Figure 2

Myeloid-derived suppressor cells (MDSCs) increased in MIBC tissues and promoted cancer progression. (a, b) Flow cytometry and statistical analysis of the proportion of MDSCs in MIBC tissues and normal urothelium from 200 patients. (c, d) Flow cytometry and statistical analysis of the proportion of MDSCs in recurrent MIBC tissues and in MIBC tissues. (e) Tumor growth rates in a MIBC mouse model with or without MDSC treatment (). (f) Tumor weight in a MIBC mouse model with or without MDSC treatment (). (g) Survival time of a MIBC mouse model with or without MDSC treatment (). , , and .

(a)

(b)

(c)

(d)

(e)

(f)

(g)