IL-6 Promotes the Proliferation and Immunosuppressive Function of Myeloid-Derived Suppressor Cells via the MAPK Signaling Pathway in Bladder Cancer

<div>IL-6 activated the mitogen-activated protein kinase (MAPK) signaling pathway in MDSCs. (a, b) Heat map of RNA sequencing results to evaluate differentially expressed genes in MDSCs with or without IL-6 treatment. (c, d) Differentially expressed genes were enriched for several signaling pathways. (e, f) Phosphorylation of critical proteins in the MAPK signaling pathway (MEK2, ERK, and MNK1) was evaluated by western blotting. 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BioMed Research International

fig5

Figure 5

Figure 5: IL-6 Promotes the Proliferation and Immunosuppressive Function of Myeloid-Derived Suppressor Cells via the MAPK Signaling Pathway in Bladder Cancer 

Figure 5 | IL-6 Promotes the Proliferation and Immunosuppressive Function of Myeloid-Derived Suppressor Cells via the MAPK Signaling Pathway in Bladder Cancer 