Abnormally Expressed lncRNAs as Potential Biomarkers for Gastric Cancer Risk: A Diagnostic Meta-Bioinformatics Analysis

Table 1

Study characteristics.

Author	Year	Ethnicity	Gene	Regulated	Location	Sample type	ROC	Cut-off	SEN	SPE	Total	Cancer	Control	Control sources	NOS	Reference
Shao et al.	2014	Chinese	AA174084	Down	Unknown	Gastric juices	0.848	0.88	0.46	0.93	130	39	91	NMMG+AG+GU	7	[21]
Shao et al.	2014	Chinese	AA174084	Down	Unknown	Tissue	0.676	11.62	0.57	0.73	268	134	134	ANT	8	[21]
Lin et al.	2014	Chinese	ABHD11-AS1	Up	Intergenic	Tissue	0.613	11	0.67	0.64	150	75	75	ANT	7	[22]
Yang et al.	2016	Chinese	ABHD11-AS1	Up	Intergenic	Gastric juices	0.653	6.53	0.41	0.934	130	39	91	NMMG+AG+GU	7	[66]
Abdi et al.	2021	Iranian	AC064834.1	Up	Unknown	Tissue	0.7	Unclear	0.675	0.675	80	40	40	ANT	7	[31]
Sun et al.	2013	Chinese	AC096655.1-002	Down	Intergenic	Tissue	0.731	13.955	0.513	0.872	156	78	78	ANT	8	[24]
Chen et al.	2014	Chinese	AC138128.1	Down	Unknown	Tissue	0.688	Unclear	0.7	0.56	188	94	94	ANT	7	[48]
Zhou et al.	2020	Chinese	BC002811	Up	Unknown	Serum	0.723	1.41	0.58	0.943	170	100	70	Benign gastric diseases	6	[60]
Zhou et al.	2020	Chinese	C5orf66-AS1	Down	Intergenic	Serum	0.688	0.134	0.775	0.536	419	141	278	GS+GA+GD	7	[12]
Roghieh et al.	2021	Iranian	DLEU1	Up	Antisense	Tissue	0.7	0.3357	0.62	0.646	100	50	50	ANT	6	[32]
Liu et al.	2014	Chinese	FER1L4	Down	Unknown	Tissue	0.778	15.43	0.672	0.803	122	61	61	ANT	8	[23]
Tan et al.	2016	Chinese	GACAT2	Up	Antisense	Plasma	0.622	6.625	0.872	0.282	197	117	80	Healthy blood	6	[61]
Arita et al.	2013	Japanese	H19	Up	Intergenic	Plasma	0.64	Unclear	0.74	0.58	76	43	33	Healthy blood	7	[49]
Zhou et al.	2015	Chinese	H19	Up	Intergenic	Plasma	0.838	Unclear	0.829	0.729	140	70	70	Healthy blood	7	[62]
Zhou et al.	2015	Chinese	H19	Up	Intergenic	Plasma (early cancer)	0.877	Unclear	0.855	0.801	52	26	26	Healthy blood	7	[62]
Chen et al.	2016	Chinese	H19	Up	Intergenic	Tissue	0.697	Unclear	0.62	0.74	256	128	128	ANT	7	[25]
Hashad et al.	2016	Egyptian	H19	Up	Intergenic	Plasma	0.724	0.5	0.6875	0.5667	62	32	30	Healthy blood	7	[53]
Yu et al.	2020	Chinese	H19	Up	Intergenic	Serum	0.943	Unclear	0.9007	0.9018	224	112	112	Healthy blood	7	[63]
Hui et al.	2021	Chinese	HEIH	Up	Intergenic	Tissue	0.784	Unclear	0.78	0.812	300	150	150	ANT	7	[33]
Sun et al.	2015	Chinese	HIF1A-AS2	Up	Antisense	Tissue	0.673	9.56	0.7229	0.6024	166	83	83	ANT	7	[39]
Xu et al.	2019	Chinese	HOTAIR	Up	Antisense	Tissue	0.8416	1.4	0.6667	0.8704	108	54	54	ANT	7	[9]
Zhao et al.	2014	Chinese	HULC	Up	Antisense	Tissue	0.769	10.88	0.707	0.724	116	58	58	ANT	7	[29]
Jin et al.	2016	Chinese	HULC	Up	Antisense	Serum	0.888	Unclear	0.82	0.836	210	100	110	Healthy blood	8	[55]
Ma et al.	2016	Chinese	KRT18P55	Up	Unknown	Tissue	0.733	Unclear	0.691	0.66	194	97	97	ANT	8	[27]
Samaneh et al.	2021	Iranian	KRT18P55	Up	Unknown	Tissue	0.6799	0.0023	0.5392	0.7745	204	102	102	ANT	7	[34]
Ji et al.	2019	Chinese	LINC00086	Down	Unknown	Plasma	0.86	0.3	0.726	0.838	242	168	74	Healthy blood	9	[54]
Pang et al.	2014	Chinese	LINC00152	Up	Intergenic	Tissue	0.645	4.385	0.625	0.681	142	71	71	ANT	6	[28]
Li et al.	2015	Chinese	LINC00152	Up	Intergenic	Plasma	0.657	Unclear	0.481	0.852	160	79	81	Healthy blood	7	[57]
Chen et al.	2016	Chinese	LINC00152	Up	Intergenic	Tissue	0.705	3.175	0.7629	0.567	194	97	97	ANT	7	[30]
Fei et al.	2016	Chinese	LINC00982	Up	Antisense	Tissue	0.742	Unclear	0.811	0.613	212	106	106	ANT	8	[14]
Liang et al.	2021	Chinese	LINC01061	Up	Intergenic	Serum	0.93	Unclear	0.717	0.965	82	53	29	Healthy blood	6	[58]
Yu et al.	2020	Chinese	linc-ROR	Down	Unknown	Tissue	0.6495	16.79	0.7524	0.5143	210	105	105	ANT	6	[35]
Liu et al.	2014	Chinese	ncRuPAR	Down	Intergenic	Tissue	0.84	4.97	0.8841	0.7391	276	138	138	ANT	7	[36]
Guo et al.	2016	Chinese	OR3A4	Up	Unknown	Plasma	0.852	Unclear	0.8694	0.9127	260	130	130	Healthy blood	7	[52]
Gao et al.	2016	Chinese	PVT1	Up	Intergenic	Plasma	0.797	Unclear	0.593	0.921	40	20	20	Healthy blood	6	[51]
Dastmalchi et al.	2021	Iranian	PVT1	Up	Intergenic	Tissue	0.71	Unclear	0.5588	0.7843	204	102	102	ANT	6	[37]
Yuan et al.	2016	Chinese	PVT1	Up	Intergenic	Tissue	0.728	Unclear	0.802	0.604	222	111	111	ANT	8	[38]
Shao et al.	2016	Chinese	RMRP	Up	Bidirectional	Plasma	0.639	Unclear	0.591	0.678	193	103	90	Healthy blood	6	[64]
Shao et al.	2016	Chinese	RMRP	Up	Bidirectional	Gastric juices	0.699	Unclear	0.564	0.754	84	39	45	Healthy juices	6	[64]
Sun et al.	2015	Chinese	RP11-119F7.4	Down	Unknown	Tissue	0.637	6.445	0.448	0.823	192	96	96	ANT	7	[39]
Mo et al.	2019	Chinese	RP11-555H23.1	Down	Unknown	Tissue	0.65	12.9	0.81	0.62	208	104	104	ANT	8	[40]
Jing et al.	2020	Chinese	RP11-731F5.2	Up	Unknown	Serum	0.78	Unclear	0.816	0.636	184	104	80	Healthy blood	6	[56]
Tang et al.	2020	Chinese	SGOL1-AS1	Up	Unknown	Tissue	0. 612	Unclear	0.877	0.4	130	65	65	ANT	6	[41]
Chen et al.	2016	Chinese	SNHG15	Up	Intronic	Tissue	0.722	4.43	0.642	0.745	212	106	106	ANT	8	[30]
Mei et al.	2013	Chinese	SUMO1P3	Up	Unknown	Tissue	0.666	2.31	0.659	0.636	192	96	96	ANT	7	[42]
Weiwei and Jianjun	2021	Chinese	TC0101441	Up	Unknown	Tissue	0.8082	8.45	0.817	0.923	318	159	159	ANT	6	[43]
Sun et al.	2015	Chinese	TINCR	Up	Intronic	Tissue	0.701	9.05	0.65	0.71	160	80	80	ANT	7	[39]
Li et al.	2021	Chinese	TUG1	Up	Intergenic	Serum	0.833	2.405	0.7419	0.8955	129	67	62	Healthy blood	9	[65]
Li et al.	2015	Chinese	UCA1	Up	Intergenic	Tissue	0.721	13.74	0.672	0.803	224	112	112	ANT	7	[57]
Gao et al.	2016	Chinese	UCA1	Up	Intergenic	Plasma	0.928	Unclear	0.892	0.803	40	20	20	Healthy blood	6	[51]
Ma et al.	2019	Chinese	ZEB1-AS1	Up	Antisense	Tissue	0.79	Unclear	0.821	0.792	143	84	59	ANT	7	[46]
Pan et al.	2017	Chinese	ZFAS1	Up	Antisense	Tissue	0.63	Unclear	0.5	0.787	188	94	94	ANT	8	[47]
Pan et al.	2017	Chinese	ZFAS1	Up	Antisense	Serum	0.792	Unclear	0.717	0.757	60	37	23	Healthy blood	6	[47]
Dastmalchi et al.	2021	Iranian	ZFAS1	Down	Antisense	Tissue	0.79	Unclear	0.6471	0.7941	204	102	102	ANT	6	[37]