| Subgroups | Number | Pooled SEN (95% CI) | test (%) SEN | Pooled SPE (95% CI) | test (%) SPE | Pooled PLR (95% CI) | test (%) PLR | Pooled NLR (95% CI) | test (%) NLR | Pooled DOR (95% CI) | test (%) DOR | AUC (95% CI) | | value |
| All studies | 54 | 0.71 (0.67, 0.74) | 84.23 | 0.76 (0.71, 0.79) | 89.04 | 2.9 (2.5, 3.4) | 83.95 | 0.39 (0.34, 0.43) | 80.61 | 8 (6, 10) | 78.9 | 0.79 (0.75, 0.82) | | | Location | | | | | | | | | | | | | | | Intergenic | 22 | 0.72 (0.66, 0.77) | 85.33 | 0.78 (0.72, 0.83) | 88.42 | 3.2 (2.5, 4.1) | 79.22 | 0.36 (0.30, 0.44) | 83.17 | 9 (6, 13) | 78.2 | 0.81 (0.78, 0.84) | -0.076 | 0.939 | Antisense | 11 | 0.73 (0.66, 0.79) | 82.51 | 0.71 (0.61, 0.80) | 90.08 | 2.6 (1.9, 3.4) | 85.94 | 0.38 (0.30, 0.47) | 74.65 | 7 (4, 10) | 71 | 0.78 (0.75, 0.82) | Sample type | | | | | | | | | | | | | | | Circulating | 19 | 0.76 (0.71, 0.81) | 84.34 | 0.79 (0.71, 0.86) | 92.98 | 3.7 (2.6, 5.3) | 91.66 | 0.3 (0.24, 0.37) | 83.61 | 12 (7, 20) | 85 | 0.84 (0.80, 0.87) | -2.582 | 0.01 | Tissue | 32 | 0.69 (0.65, 0.73) | 82.38 | 0.72 (0.68, 0.76) | 83.41 | 2.5 (2.2, 2.9) | 68.05 | 0.42 (0.38, 0.48) | 75.4 | 6 (5, 7) | 72.2 | 0.77 (0.73, 0.80) | Sample size | | | | | | | | | | | | | ≤200 | 35 | 0.68 (0.63, 0.72) | 79.78 | 0.75 (0.69, 0.79) | 87.69 | 2.7 (2.2, 3.2) | 77.63 | 0.43 (0.39, 0.48) | 65.02 | 6 (5, 8) | 57.3 | 0.76 (0.72, 0.80) | -1.259 | 0.208 | >200 | 19 | 0.75 (0.70, 0.80) | 87.58 | 0.77 (0.71, 0.82) | 91.38 | 3.2 (2.5, 4.2) | 87.41 | 0.33 (0.26, 0.41) | 88.07 | 10 (6, 15) | 88.2 | 0.82 (0.79, 0.86) | Quality | | | | | | | | | | | | | | | | 16 | 0.71 (0.65, 0.77) | 81.76 | 0.75 (0.64, 0.83) | 92.36 | 2.8 (2.0, 4.0) | 87.66 | 0.38 (0.31, 0.47) | 72.18 | 7 (5, 12) | 80 | 0.78 (0.74, 0.82) | -0.303 | 0.762 | | 38 | 0.71 (0.66, 0.75) | 85.42 | 0.76 (0.72, 0.80) | 86.63 | 3.0 (2.5, 3.5) | 77.38 | 0.39 (0.34, 0.44) | 83.21 | 8 (6, 10) | 78.9 | 0.80 (0.76, 0.83) |
|
|