BioMed Research International

Retracted: To Analyze the Mechanism of SalB Regulating SIRT1 to Inhibit NLRP3 and Its Ameliorative Effect on Tubulogastric Junction Tumor Lesions Complicated with Myocardial Injury

Good resilience skills support effective and timely adjustment to demanding situations in the workplace. Existing tools are insufficient to develop and evaluate workplace interventions to improve employee’s resilience skills. The aim of this study was to develop and validate a Resilience Skills Questionnaire (RSQ) using the key constructs of social cognitive theory—self-efficacy, self-regulation, and social support—as a theoretical framework. Following DeVellis’ guidelines for scale development, first an expert panel of thirteen professors was recruited to support the item development stages and determine content validity. At this stage, the initial pool of 38 items was reduced to 25 items and CVR and CVI were calculated as 0.92 and 0.93, respectively, indicating good content validity. A second panel of ten health professionals confirmed face validity. An online survey comprised of the 25 developed items was then completed by 336 health professionals working in urban healthcare centers in Shiraz, Iran, in November 2021. The data were used to assess the psychometrics of the questionnaire according to its hypothesized three-dimensional structure. 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Based on these results, the RSQ can be used as a standard and valid measure to develop and evaluate the effect of educational intervention programs to improve resilience skills and reduce job stress.

Maryam Akbari

Hamidreza Mokarami

Rosanna Cousins

Changiz Rahimi Taghanaki

Mohammad Hossein Kaveh

Mehdi Jahangiri

Development and Validation of a Resilience Skills Questionnaire for Health Sector Professionals Based on Social Cognitive Theory

<i>Introduction</i>. Alzheimer’s disease (AD) is a neurodegenerative disorder with no conclusive remedy. <i>Yohimbine</i>, found in <i>Rauwolfia vomitoria</i>, may reduce brain inflammation by targeting tumour necrosis factor-alpha (TNF<i>α</i>), implicated in AD pathogenesis. Metoserpate, a synthetic compound, may inhibit TNF<i>α</i>. The study is aimed at assessing the potential utility of repurposing metoserpate for TNF<i>α</i> inhibition to reduce neuronal damage and inflammation in AD. The development of safe and effective treatments for AD is crucial to address the growing burden of the disease, which is projected to double over the next two decades. <i>Methods</i>. Our study repurposed an FDA-approved drug as TNF<i>α</i> inhibitor for AD management using structural similarity studies, molecular docking, and molecular dynamics simulations. <i>Yohimbine</i> was used as a reference compound. Molecular docking used SeeSAR, and molecular dynamics simulation used GROMACS. <i>Results</i>. Metoserpate was selected from 10 compounds similar to <i>yohimbine</i> based on pharmacokinetic properties and FDA approval status. Molecular docking and simulation studies showed a stable interaction between metoserpate and TNF<i>α</i> over 100 ns (100000 ps). This suggests a reliable and robust interaction between the protein and ligand, supporting the potential utility of repurposing metoserpate for TNF<i>α</i> inhibition in AD treatment. <i>Conclusion</i>. Our study has identified metoserpate, a previously FDA-approved antihypertensive agent, as a promising candidate for inhibiting TNF<i>α</i> in the management of AD.

Edward Jenner Tettevi

Deryl Nii Okantey Kuevi

Balagra Kasim Sumabe

David Larbi Simpong

Mahmoud B. Maina

Julius T. Dongdem

Mike Y. Osei-Atweneboana

Augustine Ocloo

In Silico Identification of a Potential TNF-Alpha Binder Using a Structural Similarity: A Potential Drug Repurposing Approach to the Management of Alzheimer’s Disease

<i>Introduction</i>. The sperm DNA fragmentation index (DFI) is considered a valuable measure to assess male fertility, but the predictive value of DFI for the outcomes in assisted reproductive technology (ART) is still controversial. Therefore, this study is aimed at investigating the effect of requesting a DFI test or performing ART without DFI on the results observed in the embryology laboratory (number of embryos, fertilization rate, and embryo quality) after intracytoplasmic sperm injection (ICSI). <i>Methods</i>. This retrospective study was conducted on infertile men who underwent ICSI and were referred to the Avicenna Infertility and Recurrent Abortion Treatment Center in Tehran from 2019 to 2022. The samples were categorized into two groups: a case group with DFI measurement and a control group without DFI measurement. We conducted a comparative analysis of the embryology results between the two groups, focusing on parameters such as fertilization rate, number of embryos, and embryo quality. <span class="nowrap"><svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" style="vertical-align:-0.2063999pt" id="M1" height="8.02022pt" version="1.1" viewBox="-0.0498162 -7.81382 4.54925 8.02022" width="4.54925pt"><g transform="matrix(.013,0,0,-0.013,0,0)"><path id="g113-117" d="M324 430H196L233 583L223 592L145 529L120 430H54L29 396L31 388H111L56 126C33 15 54 -12 77 -12C137 -12 214 57 250 95L233 119C208 92 155 59 138 59C126 59 120 70 131 125L186 390L298 394L324 430Z"/></g></svg>-</span>tests and Mann–Whitney <svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" style="vertical-align:-0.2064009pt" id="M2" height="8.8423pt" version="1.1" viewBox="-0.0498162 -8.6359 9.58606 8.8423" width="9.58606pt"><g transform="matrix(.013,0,0,-0.013,0,0)"><path id="g113-86" d="M715 650H476L470 622C550 619 562 610 562 570C562 536 553 481 535 384L523 321C485 121 408 37 283 37C178 37 99 109 134 297L178 532C193 612 199 616 278 622L284 650H29L23 622C105 616 109 609 94 532L48 291C23 160 51 83 98 40C143 -1 202 -16 260 -16C321 -16 387 3 439 49C509 111 542 204 563 312L577 384C595 479 608 533 619 569C629 603 637 620 709 622L715 650Z"/></g></svg> tests were used to conduct single variable analysis. Potential confounding effects were adjusted to use the multivariate linear and logistic regression. <i>Results</i>. Data analysis showed no significant statistical difference between the case group and the control group in terms of the number of embryos (95% confidence interval for the regression coefficient <span class="inline_break"><svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" width="27.813pt" style="vertical-align:-3.42947pt" id="M3" height="12.7178pt" version="1.1" viewBox="-0.0498162 -9.28833 27.813 12.7178"><g transform="matrix(.013,0,0,-0.013,0,0)"><path id="g113-41" d="M300 -147C201 -63 143 98 143 270S200 602 300 686L282 710C136 610 70 450 70 271V270C70 89 136 -72 282 -170L300 -147Z"/></g><g transform="matrix(.013,0,0,-0.013,4.498,0)"><path id="g113-224" d="M558 587C558 666 497 712 432 712C379 712 330 691 284 650C212 586 178 508 148 348L71 -65C49 -185 35 -229 23 -235L27 -261C49 -259 101 -251 124 -224C131 -216 138 -178 159 -24C171 66 197 200 227 356C264 550 295 668 393 668C443 668 479 632 479 575C479 516 446 458 383 418C361 404 344 398 318 397L296 350C395 338 460 281 460 192C460 110 411 40 300 40C258 40 215 55 192 69L181 51C191 18 222 -16 266 -16C308 -16 351 1 397 26C471 67 545 142 545 221C545 315 486 365 401 395C469 437 558 498 558 587Z"/></g><g transform="matrix(.013,0,0,-0.013,12.052,0)"><path id="g113-42" d="M275 270C275 450 212 609 64 710L45 686C145 604 203 442 203 270S147 -63 45 -147L64 -170C213 -68 275 89 275 270Z"/></g><g transform="matrix(.013,0,0,-0.013,20.182,0)"><path id="g117-34" d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z"/></g></svg><span class="irelop"/><span class="nowrap"><svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" width="68.551pt" style="vertical-align:-3.42947pt" height="12.7178pt" version="1.1" viewBox="31.3951838 -9.28833 68.551 12.7178"><g transform="matrix(.013,0,0,-0.013,31.445,0)"><path id="g117-33" d="M535 230V280H52V230H535Z"/></g><g transform="matrix(.013,0,0,-0.013,39.076,0)"><path id="g113-49" d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"/></g><g transform="matrix(.013,0,0,-0.013,45.316,0)"><path id="g113-47" d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z"/></g><g transform="matrix(.013,0,0,-0.013,48.28,0)"><path id="g113-51" d="M412 140C382 77 369 73 315 73H129L270 222C362 320 402 379 402 466C402 571 322 635 234 635C177 635 130 609 99 576L42 495L64 475C90 514 133 568 201 568C274 568 318 519 318 435C318 349 255 267 193 193C144 135 87 78 32 23V0H405C417 45 427 89 440 131L412 140Z"/></g><g transform="matrix(.013,0,0,-0.013,54.52,0)"><path id="g113-54" d="M153 550H386L412 615L406 623H120L82 318C104 327 142 338 184 338C294 338 347 275 347 187C347 112 305 39 221 39C160 39 119 71 97 89C88 97 80 96 71 90C59 80 50 67 49 57C48 45 52 36 66 23C80 9 123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z"/></g><g transform="matrix(.013,0,0,-0.013,60.76,0)"><path id="g113-56" d="M447 623H65C61 580 56 530 47 475H76C100 541 106 550 172 550H388C308 376 196 170 91 -1L98 -12L172 -2C268 204 360 408 455 611L447 623Z"/></g><g transform="matrix(.013,0,0,-0.013,67.002,0)"><path id="g190-46" d="M300 253H71L57 198H286L300 253Z"/></g><g transform="matrix(.013,0,0,-0.013,71.648,0)"><use xlink:href="#g113-49"/></g><g transform="matrix(.013,0,0,-0.013,77.888,0)"><use xlink:href="#g113-47"/></g><g transform="matrix(.013,0,0,-0.013,80.852,0)"><path id="g113-50" d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"/></g><g transform="matrix(.013,0,0,-0.013,87.092,0)"><use xlink:href="#g113-51"/></g><g transform="matrix(.013,0,0,-0.013,93.332,0)"><path id="g113-52" d="M285 378C315 398 338 416 353 432C373 451 384 474 384 503C384 579 325 635 236 635H235C182 635 136 610 108 579L65 516L85 496C110 533 150 575 205 575C258 575 300 543 300 481C300 407 232 369 141 339L147 310C163 315 188 321 211 321C268 321 338 284 338 192C338 94 288 40 217 40C160 40 119 68 93 91C85 98 77 97 69 91C60 84 47 71 46 58C44 46 48 35 62 22C75 10 116 -12 162 -12C234 -12 424 62 424 224C424 297 373 359 285 376V378Z"/></g></svg>),</span></span> and embryo quality (95% confidence interval for <span class="inline_break"><svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" width="18.817pt" style="vertical-align:-3.42947pt" id="M4" height="12.7178pt" version="1.1" viewBox="-0.0498162 -9.28833 18.817 12.7178"><g transform="matrix(.013,0,0,-0.013,0,0)"><use xlink:href="#g113-224"/></g><g transform="matrix(.013,0,0,-0.013,11.186,0)"><use xlink:href="#g117-34"/></g></svg><span class="irelop"/><span class="nowrap"><svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" width="68.518pt" style="vertical-align:-3.42947pt" height="12.7178pt" version="1.1" viewBox="22.399183800000003 -9.28833 68.518 12.7178"><g transform="matrix(.013,0,0,-0.013,22.449,0)"><use xlink:href="#g117-33"/></g><g transform="matrix(.013,0,0,-0.013,30.08,0)"><use xlink:href="#g113-49"/></g><g transform="matrix(.013,0,0,-0.013,36.32,0)"><use xlink:href="#g113-47"/></g><g transform="matrix(.013,0,0,-0.013,39.284,0)"><use xlink:href="#g113-50"/></g><g transform="matrix(.013,0,0,-0.013,45.524,0)"><path id="g113-58" d="M244 635C114 635 38 519 38 422C38 317 111 240 217 240C236 240 255 244 277 256L345 292C311 140 203 39 59 15L64 -15C89 -15 150 -5 204 17C339 72 440 202 440 386C440 521 368 635 244 635ZM228 602C326 602 352 479 352 390C352 370 351 347 348 324C327 308 293 296 258 296C174 296 124 369 124 458C124 517 152 602 228 602Z"/></g><g transform="matrix(.013,0,0,-0.013,51.765,0)"><use xlink:href="#g113-58"/></g><g transform="matrix(.013,0,0,-0.013,58.006,0)"><use xlink:href="#g190-46"/></g><g transform="matrix(.013,0,0,-0.013,62.652,0)"><use xlink:href="#g113-49"/></g><g transform="matrix(.013,0,0,-0.013,68.892,0)"><use xlink:href="#g113-47"/></g><g transform="matrix(.013,0,0,-0.013,71.856,0)"><use xlink:href="#g113-50"/></g><g transform="matrix(.013,0,0,-0.013,78.096,0)"><use xlink:href="#g113-50"/></g><g transform="matrix(.013,0,0,-0.013,84.336,0)"><path id="g113-53" d="M456 178V225H360V632H320C217 496 115 347 20 206V178H280V106C280 40 276 34 189 27V0H445V27C364 34 360 39 360 106V178H456ZM280 225H82C149 335 214 431 278 520H280V225Z"/></g></svg>).</span></span> There was no significant statistical difference between the two groups due to the fertilization rate (95% confidence interval for <span class="inline_break"><svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" width="18.817pt" style="vertical-align:-3.42947pt" id="M5" height="12.7178pt" version="1.1" viewBox="-0.0498162 -9.28833 18.817 12.7178"><g transform="matrix(.013,0,0,-0.013,0,0)"><use xlink:href="#g113-224"/></g><g transform="matrix(.013,0,0,-0.013,11.186,0)"><use xlink:href="#g117-34"/></g></svg><span class="irelop"/><span class="nowrap"><svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" width="55.991pt" style="vertical-align:-3.42947pt" height="12.7178pt" version="1.1" viewBox="22.399183800000003 -9.28833 55.991 12.7178"><g transform="matrix(.013,0,0,-0.013,22.449,0)"><use xlink:href="#g117-33"/></g><g transform="matrix(.013,0,0,-0.013,30.08,0)"><use xlink:href="#g113-52"/></g><g transform="matrix(.013,0,0,-0.013,36.32,0)"><use xlink:href="#g113-47"/></g><g transform="matrix(.013,0,0,-0.013,39.284,0)"><use xlink:href="#g113-53"/></g><g transform="matrix(.013,0,0,-0.013,45.524,0)"><use xlink:href="#g113-51"/></g><g transform="matrix(.013,0,0,-0.013,51.764,0)"><use xlink:href="#g190-46"/></g><g transform="matrix(.013,0,0,-0.013,56.41,0)"><use xlink:href="#g113-52"/></g><g transform="matrix(.013,0,0,-0.013,62.65,0)"><use xlink:href="#g113-47"/></g><g transform="matrix(.013,0,0,-0.013,65.614,0)"><use xlink:href="#g113-53"/></g><g transform="matrix(.013,0,0,-0.013,71.854,0)"><use xlink:href="#g113-51"/></g></svg>),</span></span> except for the variables of woman’s age and sperm count after ICSI, as determined by adjusted linear regression. <i>Conclusions</i>. Although DFI measurement is used to assess male infertility, its importance as a predictor for the embryology outcomes after ICSI requires further evaluation and the determination of a cut-off point for predicting results. This study was based on retrospectively collected DFI data, and prospective studies confirming the superiority of ICSI outcomes are necessary.

Naser AmirJannati

Arash Mohazzab

Manizheh Fathalian

Hamed Akhavizadegan

Comparison of Embryological Results of Microinjection in Two Groups of Men with and without Requesting Sperm DNA Fragmentation Index Measurement

<i>Background</i>. Traditional herbal medicine practitioners in the Ashanti region of Ghana use the fruit peels of <i>Citrus limon</i> (L.) Osbeck (<i>C. limon</i>) in preventive and curative treatment of many cancers including liver cancer. This ethnobotanical claim remains to be verified scientifically. <i>Aim of the Study</i>. This study investigated prophylactic hepatoprotective and anti-HCC effects of <i>C. limon</i> peel extract (LPE) in CCl<sub>4</sub>/olive oil-induced HCC-like rats. <i>Materials and Methods</i>. After preparation of LPE, it was subjected to phytochemical screening using standard phytochemical methods. A total of 30 healthy adult male Sprague-Dawley rats (weighing 150-200 g) were randomly assigned into six groups of 5 rats each. Rats in the control group received olive oil (5 mL/kg <i>ip</i>) twice weekly for 16 weeks. Rats in the model group received CCl<sub>4</sub>/olive oil (2 mL/kg, <i>ip</i>) twice weekly for 16 weeks. Rats in capecitabine (10 mg/kg <i>po</i>) and LPE (50, 100, and 200 mg/kg <i>po</i>) groups received CCl<sub>4</sub>/olive oil (2 mL/kg, <i>i.p</i>) in the morning and their respective treatments in the afternoon twice a week for 16 weeks. Rats in all groups had free access to food and water <i>ad libitum</i>. Body weight and survival rates were monitored. Rats were sacrificed under deep anesthesia, blood was collected, and liver and other organs were isolated. Aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT), prothrombin time, bilirubin, C-reactive protein (CRP), alpha- (<i>α</i>-) fetoprotein (AFP), and liver histology were assessed. <i>Results</i>. Alkaloids, tannins, flavonoids, terpenoids, and saponins were detected in LPE. Model rats demonstrated increased serum levels of AFP, CRP, ALP, GGT, ALT, and AST, prothrombin time, total bilirubin, direct bilirubin, blood lymphocyte, and monocyte counts, but decreased serum albumin and total protein compared to control rats. Unlike the control, model rats demonstrated fat accumulation in periportal and centrilobular hepatocytes and neoplastic transformation. Semiquantitation of periodic acid Schiff- (PAS-) stained liver sections showed decreased glycogen storage in hepatocytes of model rats compared to control rats. Compared to the model, LPE treatment protected against CCl4-induced hepatocarcinogenesis, which was evidenced by decreased AFP, CRP, liver enzymes, total and direct bilirubin, prothrombin time, and blood lymphocyte and monocyte counts; attenuation of fat accumulation; and increased glycogen storage, albumin, and total protein. <i>Conclusion</i>. LPE abates CCl<sub>4</sub>-induced hepatocarcinogenesis by attenuating liver inflammation and improving metabolic, biosynthetic, and detoxification functions of the liver. The prophylactic hepatoprotective and anti-hepatocarcinogenic effects of LPE are attributable to its phytochemical composition raising hopes of finding potential anticancer bioactive compounds from <i>C. limon</i> fruit peels.

Alex Boye

Ernest Amponsah Asiamah

Orleans Martey

Frederick Ayertey

<i>Citrus limon</i> (L.) Osbeck Fruit Peel Extract Attenuates Carbon Tetrachloride-Induced Hepatocarcinogenesis in Sprague-Dawley Rats

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BioMed Research International publishes original research articles and review articles covering a wide range of subjects within the biomedical sciences. The journal will accept both basic and translational research.

BioMed Research International