Aberrant gene expression is an important pathological mechanism that is subject to tight control at multiple steps, including transcription, mRNA splicing, and translation. Genetic mutations in germline or somatic cells lead to expression alteration of the cognate or downstream genes. Nutrition and environmental factors may affect human health via modulation of gene expression; one major function of epigenetic pathways is the transcriptional silencing/activation. For this reason, transcriptional factors are used as biomarkers for diagnosis and/or risk evaluations. Since gene regulation is sensitive to preventive or therapeutic interference and is directly related to the outcomes of management procedures, understanding of gene regulation is often required for the development of new treatment modalities.

This special issue will focus on gene regulation in obstetric, gynecologic, and reproductive diseases. We invite investigators to contribute with original and review articles that will enrich our knowledge on gene regulation alterations that are relevant to the mechanisms, diagnosis, and treatment of infertility and abnormality of reproductive endocrinology, preeclampsia, and gynecologic cancers, although an excellent manuscript with a clear focus on gene regulation mechanism in other systems will also be considered. Priority for publication is given to new findings applying novel approach, models, or study subjects.

Potential topics include, but are not limited to:

• Gene regulation and its involvement in the pathogenesis of obstetric, gynecologic, and reproductive diseases
• Epigenetic alterations, including those in DNA methylation, chromatin remodeling, and noncoding RNA
• Gene regulation by endogenous and exogenous hormones and nutrition, life style, and environmental factors in reproductive system
• Transcription regulators and epigenetic factors as biomarkers or therapeutic targets for the management of obstetric, gynecologic, and reproductive diseases