BioMed Research International

Modulation of Lung Immune Response 2014


Status
Published

1Universidade Federal do Triângulo Mineiro, Uberaba, Brazil

2Reference Centers for Innovative Technologies Foundation (CERTI), Florianopolis, Brazil

3Harvard Medical School, Boston, USA


Modulation of Lung Immune Response 2014

Description

In recent decades, considerable progress has been made in the understanding of genetic and immunological factors that contribute to the development and/or treatment of airway disorders. The use of molecular and cellular assays together with knockout animals has contributed significantly to this evolution. Despite this, the current therapy for the treatment of airway disorders has not changed to the same degree and is still far from ideal.

In an attempt to respond to this need, one of the areas that have been highlighted most recently is immunology. Knowledge of the participation of the innate and adaptive immune response in the pathophysiological process of infectious and noninfectious airway injuries is rapidly expanding and the advances in the fields of biomedicine and biotechnology have been decisive to this expansion. The innate and adaptive immune system, as well as structural cells, modulate the quantity and quality of airway inflammatory response. Aberrant immune responses, including those induced for allergens, environmental pollutants, infectious agents, acids, and others, promote excessive leukocyte recruitment, production of proinflammatory cytokines, chemokines, and other immunomodulatory mediators which are critical to the initiation and maintenance of airway disorders. So, we take a particular interest in manuscripts on the relevance of structural cells, innate and adaptive host responses on modulation/induction, repair, or therapy in the airways. Reviews and original papers that demonstrate the results of clinical, preclinical, or experimental studies of cytokines, antibodies, peptides, RNA interference (RNAi), substances from plants, or other origins that modify immune response for therapeutic purposes are also welcome. In addition, once nanotechnology has a profound impact on many scientific fields and an exponential growth, the impact of colloidal drug delivery systems as carriers for bioactive agents (active substances) in the airways will be interesting. Moreover, papers dealing with detection methods of innate immune parameters in the airways as well as the demonstration of new models to analyze airway disorders would be also interesting.

Potential topics include, but are not limited to:

  • The role of innate and adaptive immune system and structural cells in airway disorders
  • The role of cytokines, chemokines, and lipid mediators in airway disorders
  • Infectious lung diseases
  • Modulation of airway inflammation
  • Preclinical and clinical studies of acute and chronic lung inflammation
  • Preclinical and clinical assays evaluating compounds or mediators with the potential to be used in the treatment of airway disorders
  • Identification of natural or synthetic bioactive molecules with potential to be used in the treatment of airway disorders

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 319593
  • - Editorial

Modulation of Lung Immune Response 2014

Alexandre de Paula Rogerio | Carlo José Freire Oliveira | ... | Troy Carlo
  • Special Issue
  • - Volume 2015
  • - Article ID 875723
  • - Review Article

Immunological, Viral, Environmental, and Individual Factors Modulating Lung Immune Response to Respiratory Syncytial Virus

Silvia Vandini | Paolo Bottau | ... | Marcello Lanari
  • Special Issue
  • - Volume 2015
  • - Article ID 317465
  • - Review Article

Advances in Anti-IgE Therapy

Arzu Didem Yalcin
  • Special Issue
  • - Volume 2015
  • - Article ID 178369
  • - Research Article

AT-RvD1 Modulates CCL-2 and CXCL-8 Production and NF-κB, STAT-6, SOCS1, and SOCS3 Expression on Bronchial Epithelial Cells Stimulated with IL-4

Jhony Robison de Oliveira | Daniely Cornélio Favarin | ... | Alexandre de Paula Rogério
  • Special Issue
  • - Volume 2015
  • - Article ID 647952
  • - Research Article

Does Moderate Intensity Exercise Attenuate the Postprandial Lipemic and Airway Inflammatory Response to a High-Fat Meal?

Stephanie P. Kurti | Sara K. Rosenkranz | ... | Craig A. Harms
  • Special Issue
  • - Volume 2015
  • - Article ID 591237
  • - Research Article

Expression Pattern of Transcription Factors and Intracellular Cytokines Reveals That Clinically Cured Tuberculosis Is Accompanied by an Increase in Mycobacterium-Specific Th1, Th2, and Th17 Cells

Marcos V. da Silva | Vladimir J. Massaro Junior | ... | Virmondes Rodrigues
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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