BioMed Research International

Prostate Cancer: From Genomics to the Whole Body and Beyond


Status
Published

Lead Editor

1Humanitas Clinical and Research Center, Milan, Italy

2Humanitas Castellanza, Varese, Italy

3University of Miami Miller School of Medicine, Miami, USA

4Humanitas Research Hospital, Milan, Italy


Prostate Cancer: From Genomics to the Whole Body and Beyond

Description

Despite rapid advances in the fields of molecular and cell biology, it is still widely debated as to how neoplastic prostate cells progress through carcinogenesis. Prostate cancer is the second most prevalent cancer in men globally. Prostate, lung and bronchus, and colorectal cancers account for 44% of all cases in men, with prostate cancer alone accounting for 1 in 5 new diagnoses.

Cancer research has generated an intricate “body of knowledge” showing that prostate cancer is a disease that involves dynamic changes in the genome. Prostate cancer is a dynamic system that is discontinuous in space and time but advances through qualitatively different states, that is, the configuration of a system at any particular instant that is specified by a great number of dynamic variables.

Viewing cancer as a system that is dynamically complex in time and space will probably reveal more about its underlying behavioral characteristics. This way of thinking may further help to clarify concepts, interpret new and old experimental data, indicate alternative experiments, and categorize the acquired knowledge on prostate cancer and its precursor lesions. It is encouraging that medicine, biology, psychology, and mathematics continue to contribute together towards a comprehensive understanding of prostate cancer complexity.

We invite authors to contribute original articles, papers, and reviews that will illustrate prostate cancer as one of the most complex diseases, determined by distinct processes and controls operating over much broader scales and by structural controls that may operate at scales ranging from molecular to environmental. The primary aims are to investigate prostate cancer as a complex nonlinear disease, to propose mathematical models that aid the comprehension of this neoplasia, and to discover diagnostic, predictive biomarkers or potential targets for the development of new and more efficacious therapeutic strategies.

Potential topics include but are not limited to the following:

  • Recent discoveries on the prostate cancer genomics
  • Proteomics and bioinformatics in prostate cancer research
  • New diagnostic and predictive tissue and serum biomarkers of prostate cancer
  • Computer-aided image analysis systems in prostate cancer research
  • Mathematical modeling of prostate cancer dynamics
  • Development of innovative therapeutic strategies for treating prostate cancer
  • Psychological effects on men with prostate cancer and their partners

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 8707690
  • - Editorial

Prostate Cancer: From Genomics to the Whole Body and Beyond

Fabio Grizzi | Gianluigi Taverna | ... | Giorgio Guazzoni
  • Special Issue
  • - Volume 2017
  • - Article ID 7206307
  • - Review Article

Establishment and Application of Prostate Cancer Circulating Tumor Cells in the Era of Precision Medicine

Yoon Seok Suh | Jae Young Joung | ... | Kang Hyun Lee
  • Special Issue
  • - Volume 2017
  • - Article ID 7450459
  • - Research Article

Pretreatment Serum Cystatin C Levels Predict Renal Function, but Not Tumor Characteristics, in Patients with Prostate Neoplasia

Feilong Yang | Dawei Li | ... | Zhonghua Xu
  • Special Issue
  • - Volume 2017
  • - Article ID 3507671
  • - Review Article

Genotyping the High Altitude Mestizo Ecuadorian Population Affected with Prostate Cancer

Andrés López-Cortés | Alejandro Cabrera-Andrade | ... | César Paz-y-Miño
  • Special Issue
  • - Volume 2017
  • - Article ID 9615080
  • - Research Article

The Long-Term Effect of Radical Prostatectomy on Erectile Function, Urinary Continence, and Lower Urinary Tract Symptoms: A Comparison to Age-Matched Healthy Controls

Badereddin Mohamad Al-Ali | Anton Ponholzer | ... | Karl Pummer
  • Special Issue
  • - Volume 2016
  • - Article ID 6963582
  • - Research Article

ZFP91: A Noncanonical NF-κB Signaling Pathway Regulator with Oncogenic Properties Is Overexpressed in Prostate Cancer

Lukasz Paschke | Karol Jopek | ... | Ludwik K. Malendowicz
  • Special Issue
  • - Volume 2016
  • - Article ID 5730569
  • - Research Article

Diet, Lifestyles, Family History, and Prostate Cancer Incidence in an East Algerian Patient Group

Somia Lassed | Cláudia M. Deus | ... | Djamila Zama
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
 Submit