BioMed Research International

Cytotoxic T Lymphocytes and Vaccine Development


Publishing date
01 Jun 2010
Status
Published
Submission deadline
01 Dec 2009

Lead Editor

1Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA

2Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA

3Department of Infectious Disease, School of Veterinary Medicine China Agricultural University, Beijing 100094, China


Cytotoxic T Lymphocytes and Vaccine Development

Description

As one of the major players in adaptive immunity, cytotoxic T Lymphocytes (CTLs) play a critical role in the control of many infections and cancers. More importantly, induction of long-lasting functional CTLs has become a goal for the modern vaccination, especially for chronic infectious diseases. However, to achieve this goal, CTLs have to be appropriately activated and programmed. The molecular mechanisms of CTL activation are just starting to be understood and have been shown to be related to antigenic stimulation, expression of distinct costimulatory molecules, and inflammatory cytokines. In addition, provision of these stimuli may differ with distinct infections due to the tissue-specificity of the pathogen, chronicity or persistence of antigen, differences in antigen presentation, and/ or the cytokine milieu. By increasing our overall understanding of how these factors modulate CTL responses, we can design multifaceted vaccines which augment the development of functional, long-lasting memory CTLs in addition to neutralizing antibodies.

We invite authors to present original research articles as well as review articles that will stimulate the continuing efforts in defining the factors involved in CTL activation and the development of immunological memory. We are particularly interested in manuscripts that report the molecular mechanisms required for the development of effector and memory CTLs, CTL responses in specific infections in animals and humans, test different strategies of memory CTL induction, and reports of new assays to evaluate CTL function. Reviews that summarize the results of latest discoveries and their implications on vaccination in economically important animals, the regulation of CTL responses by immune cells such as dendritic cells, CD4 and regulatory cells, as well as molecular mechanisms of CTL killing function are particularly welcome. Potential topics include but are not limited to:

  • Molecular mechanisms of CTL activation and programming
  • Signal transduction for CTL migration
  • Regulation of CTL induction and function by regulatory cells
  • Molecular and epigenetic mechanisms of functional memory T cell development
  • Characterization of CTL responses in infections in animals and humans
  • Novel vaccine approaches for the induction of functional memory CTLs
  • New assays for the evaluation of CTL activation

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jbb/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2010
  • - Article ID 936549
  • - Editorial

Cytotoxic T Lymphocytes and Vaccine Development

Zhengguo Xiao | Kim Klonowski | Hanchun Yang
  • Special Issue
  • - Volume 2010
  • - Article ID 846872
  • - Review Article

Tumor Microenvironment and Immune Effects of Antineoplastic Therapy in Lymphoproliferative Syndromes

Tomás Álvaro | Luis de la Cruz-Merino | ... | Mariano Provencio
  • Special Issue
  • - Volume 2010
  • - Article ID 596432
  • - Review Article

Strategies for Cancer Vaccine Development

Matteo Vergati | Chiara Intrivici | ... | Kwong Y. Tsang
  • Special Issue
  • - Volume 2010
  • - Article ID 690438
  • - Review Article

Immunomodulatory Effects of dsRNA and Its Potential as Vaccine Adjuvant

Bo Jin | Tao Sun | ... | Anthony E. T. Yeo
  • Special Issue
  • - Volume 2010
  • - Article ID 386545
  • - Research Article

Cell Density Plays a Critical Role in Ex Vivo Expansion of T Cells for Adoptive Immunotherapy

Qiangzhong Ma | Yawen Wang | ... | Richard P. Junghans
  • Special Issue
  • - Volume 2010
  • - Article ID 237623
  • - Review Article

Therapeutic Cancer Vaccines in Combination with Conventional Therapy

Mads Hald Andersen | Niels Junker | ... | Per thor Straten
  • Special Issue
  • - Volume 2010
  • - Article ID 249482
  • - Review Article

Direct Microbicidal Activity of Cytotoxic T-Lymphocytes

Paul Oykhman | Christopher H. Mody
  • Special Issue
  • - Volume 2010
  • - Article ID 907092
  • - Review Article

The Emerging Role of HLA-E-Restricted CD8+ T Lymphocytes in the Adaptive Immune Response to Pathogens and Tumors

Gabriella Pietra | Chiara Romagnani | ... | Maria Cristina Mingari
  • Special Issue
  • - Volume 2010
  • - Article ID 242539
  • - Review Article

Recent Advancements in Cytotoxic T Lymphocyte Generation Methods Using Carbohydrate-Coated Liposomes

Yuzuru Ikehara | Masahiro Yamanaka | Takashi Yamaguchi
  • Special Issue
  • - Volume 2010
  • - Article ID 102758
  • - Review Article

TAA Polyepitope DNA-Based Vaccines: A Potential Tool for Cancer Therapy

Roberto Bei | Antonio Scardino
BioMed Research International
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