Muscular Dystrophy: Disease Mechanisms and Therapies
1The George Washington University, Washington, USA
2Miami Children’s Hospital, Miami, USA
3University of Alberta, Edmonton, Canada
4Food and Drug Administration, Bethesda, USA
Muscular Dystrophy: Disease Mechanisms and Therapies
Description
In this special issue, we intend to invite researchers to submit original research and review articles on exploring molecular mechanisms and targeted therapy of muscular dystrophy. Studies may involve molecular mechanisms involved in development and treatment of diseases which is often not known and needs more research.
More specifically, this issue will give insight into cellular and molecular mechanism, activation of signaling pathways, how activation of these pathways causes muscle dysfunction, and subsequent disease symptoms. In addition, targeted therapeutic interventions and actions of therapies will be considered.
Potential topics include, but are not limited to:
- Disease mechanism of muscular dystrophies
- Molecular mechanisms regulating age-associated muscle wasting and the physiopathology of muscular dystrophies, including the contribution of inflammation and fibrosis to dystrophy progression
- Animal models of muscle pathologies or diseases
- New emerging areas of research including new paths for gene and stem cell-based therapeutic strategies for muscular dystrophies
- Antisense therapy approaches to suppress or eliminate the diseases using DNA-like molecules