Globally, hepatocellular carcinoma (HCC) has had a continuous increase in incidence over the last two decades. Its development has a complicated process and correlates to numerous factors including hepatitis viruses, intoxication, diabetes, obesity, and smoking. Hepatitis virus B and C have long been related to the etiology of HCC and long-time liver cirrhosis resulted from hepatitis B/C virus infection is responsible for its establishment and progression in a multistep process. Recently, HCC has been reported to be promoted by bacterial translocation implying the potential of chemoprevention. Molecular links are also identified, which characterize tumorigenic intracellular pathways and suggest molecular targeted therapies. There are many therapeutic modalities for treatment of HCC but evidence-based approach to the multidisciplinary management is of paramount importance.

We invite authors to contribute original research and review articles that will stimulate the lasting exertion to unveil the mechanism of HCC development and progression, with special interest in articles that cast new insights into HCC establishment and management. Potential topics include, but are not limited to:

• Recent developments in early diagnosis of HCC
• Advances in liver cirrhosis risks, imaging, and management
• Chemoprevention of liver carcinogenesis
• Curative therapy and prevention of recurrence
• Transjugular intrahepatic portosystemic shunt as a bridge for liver transplantation
• Transcatheter arterial chemoembolization
• Radiofrequency ablation of HCC
• Laparoscopic microwave coagulation therapy for HCC
• Biomarkers for diagnosis of HCC
• Antiviral therapy for prevention of postoperative recurrence
• p53 gene therapy of HCC
• Multifactors for hepatocarcinogenesis
• Inflammation and HCC
• Recent advances in comprehensive treatment of HCC

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/hepatology/hccs/ according to the following timetable: