The material-dependent immune-response elicited by the introduction of a biomaterial is known as the foreign body reaction (FBR).

It is reported that the imbalance of FBR may lead to inflammation around the implant materials, resulting in failure. For this reason, it is crucial to embrace the concept of immune-modulating biomaterials to achieve a predictable outcome. There are various strategies, including synthesis of immune-modulation polymers, modification of surface topography, loading cytokines and combination of immune-activated cells, etc.

The aim of this Special Issue is to solicit original research articles focussing on different aspects of immune-modulating strategies to achieve regeneration in a specific tissue, and help further investigate the underlying mechanisms, cell heterogeneity, and signaling transduction in a biomaterial-mediated healing process. Review articles discussing the state of the art are also welcome.

Potential topics include but are not limited to the following:

• Three-dimensional (3D) printing approaches related to immune-modulating strategies for tissue engineering
• Role of immune modulation in tissue healing
• Regulating the behaviour of macrophages through biomaterials can guide tissue regeneration
• Advances in immune-modulating biomaterials for tissue regeneration
• Biomaterial strategies for bone regeneration through immune-modulating strategy
• Potential mechanisms underlying immune-modulating strategy
• Immune-modulating therapeutic effects of scaffolds manufactured from natural extracts
• Potential of extracellular matrix (ECM) mimicking biomaterials in tissue engineering
• Relationship between tissue integration, fibrous capsule formation, and foreign body reaction (FBR)
• Regenerative advantages of electrospinning nano-fibrous membrane