BioMed Research International

Translational Research in Peripheral Nerve Repair and Regeneration


Lead Editor

1Department of Plastic, Hand and Reconstructive Microsurgery, St. Mary Hospital, Berlin, Germany

2Department of Clinical and Biological Sciences & Neuroscience Institute, Cavalieri Ottolenghi, University of Torino, 10043 Orbassano, Italy

3Department of Plastic Surgery, UNESP, Botucatu, Brazil

Translational Research in Peripheral Nerve Repair and Regeneration


The interest towards research in peripheral nerve repair regeneration has seen a great and progressive increase in the light of the continuous increase in number of microsurgical nerve reconstructions worldwide. While only few years ago nerve reconstruction was a rare type of surgery carried out in few highly specialized centers only, today it is becoming more and more frequent and widespread, and, considering the great number of traumatic events which could benefit from such type of surgery, this increasing tendency is going to continue in the future making tomorrow’s complex surgical interventions (such as limb replantation and brachial plexus reconstruction) routinary. However, peripheral nerve repair is no longer a matter of surgical reconstruction only but rather a matter of tissue engineering which brings together several interdisciplinary and integrated treatment strategies (from molecular biology and biomaterials to cell transplantation and physical therapy).

We invite investigators to contribute original research articles and reviews addressing the most promising innovative strategies for promoting peripheral nerve repair and regeneration that emerge from basic research in the different relevant scientific areas. We are particularly interested in translational research which foresees bridges between the laboratory bench and the patient’s bed. Potential topics include, but are not limited to:

  • Schwann cell biology
  • Neurotrophic and gliotrophic factors
  • Inflammatory cytokines
  • Axon guidance and neurotropism
  • Cell and tissue transplantation
  • Gene therapy
  • Nerve scaffolds
  • Biomaterials
  • Controlled molecule release
  • End-to-side neurorrhaphy
  • Nerve transfers and direct muscle neurotization
  • CNS plasticity following nerve injury and repair
  • Physical therapy
  • Target-organ atrophy prevention

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