BioMed Research International

Applications of Bioinformatics and Systems Biology in Precision Medicine and Immunooncology


Status
Published

Lead Editor
Guest Editors

1Shanghai University, Shanghai, China

2Chinese Academy of Sciences, Shanghai, China

3Mount Sinai Medical Center, New York, USA


Applications of Bioinformatics and Systems Biology in Precision Medicine and Immunooncology

Description

Next-Generation Sequencing (NGS) technology, often seen as the foundation of precision medicine, has been successfully applied in oncology diagnostics and immunotherapy. With advances in gene diagnostics and immunotherapy, there may be a chance to control the development of cancers and alleviate the suffering of patients undergoing chemotherapy.

To promote the translation of precision medicine from bench to beside and from application of genetic testing to personalized medicine, new analysis methods for NGS and genetic data need to be developed. For example, the NGS panel is quite different from whole genome sequencing (WGS), focusing on fewer genes or regions but requiring greater precision and efficiency. For complex diseases, such as cancers, the driver genes are usually a cluster of genes in a regulatory network. Graph theories, such as shortest path analysis and random walk algorithms, will help dissect genome-wide interactions into key modules or paths whose dysfunction are associated with disease progression.

We invite investigators to contribute research as well as review articles on applications of bioinformatics and systems biology in precision medicine and immunooncology.

Potential topics include but are not limited to the following:

  • Disease gene identification
  • Biomarker discovery
  • NGS panel development
  • Liquid biopsy
  • Immunotherapy
  • Antibody drug development
  • Patient-derived xenograft (PDX) models
  • Cell-free tumor DNA
  • Single-cell sequencing
  • Microsatellite instability (MSI)

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 1427978
  • - Editorial

Applications of Bioinformatics and Systems Biology in Precision Medicine and Immunooncology

Yudong Cai | Tao Huang | Jialiang Yang
  • Special Issue
  • - Volume 2018
  • - Article ID 9594568
  • - Research Article

Association of p16 as Prognostic Factors for Oropharyngeal Cancer: Evaluation of p16 in 1470 Patients for a 16 Year Study in Northeast China

Hong-xue Meng | Su-sheng Miao | ... | Jing-shu Geng
  • Special Issue
  • - Volume 2018
  • - Article ID 5670210
  • - Research Article

Pathway Network Analysis of Complex Diseases Based on Multiple Biological Networks

Fang Zheng | Le Wei | ... | FuChuan Ni
  • Special Issue
  • - Volume 2018
  • - Article ID 1501430
  • - Research Article

Genetic Polymorphism Study on Aedes albopictus of Different Geographical Regions Based on DNA Barcoding

Yiliang Fang | Jianqing Zhang | ... | Bo Gao
  • Special Issue
  • - Volume 2018
  • - Article ID 1096079
  • - Research Article

Isolation of a Reassortant H1N2 Swine Flu Strain of Type “Swine-Human-Avian” and Its Genetic Variability Analysis

Long-Bai Wang | Qiu-Yong Chen | ... | Lun-Jiang Zhou
  • Special Issue
  • - Volume 2018
  • - Article ID 9321270
  • - Research Article

Abnormal Liver Function Induced by Space-Occupying Lesions Is Associated with Unfavorable Oncologic Outcome in Patients with Colorectal Cancer Liver Metastases

Zheng Jiang | Chunxiang Li | ... | Xishan Wang
  • Special Issue
  • - Volume 2018
  • - Article ID 5830547
  • - Research Article

Correlation between the Expression of PD-L1 and Clinicopathological Features in Patients with Thymic Epithelial Tumors

Yanmei Chen | Yuping Zhang | ... | Yunxiang Zhang
  • Special Issue
  • - Volume 2018
  • - Article ID 4761064
  • - Research Article

Identification of Key Genes and miRNAs in Osteosarcoma Patients with Chemoresistance by Bioinformatics Analysis

Binbin Xie | Yiran Li | ... | Dake Chen
  • Special Issue
  • - Volume 2018
  • - Article ID 3453706
  • - Research Article

High Mobility Group Box Protein 1 Serves as a Potential Prognostic Marker of Lung Cancer and Promotes Its Invasion and Metastasis by Matrix Metalloproteinase-2 in a Nuclear Factor-κB-Dependent Manner

Xiaojin Wu | Weitao Wang | ... | Dongsheng Pei
  • Special Issue
  • - Volume 2018
  • - Article ID 8406857
  • - Research Article

Computational Approach to Investigating Key GO Terms and KEGG Pathways Associated with CNV

YuanYuan Luo | Yan Yan | ... | Zhen Li
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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