Osteochondral injuries of all types, such as accidental trauma, fractures, burns, and surgical intervention due to tumours, may both damage articular cartilage and cause bone defects. Although our body presents a well-orchestrated, physiological process of healing, which leads to structural and functional restoration of the articular cartilage and the bone defects, there are still some circumstances under which bone and articular cartilage cannot be restored without medicine’s effect.

At present, many classic drugs have been applied to regenerate articular cartilage and/or bone defects, according to their designed mechanism. Interestingly, when these classic drugs were used for their designed purpose, some novel promoting effects could be found during cartilage and bone regeneration. This is because these drugs also promote proliferation and differentiation of mesenchymal stem cells into cartilage-specific cell types, as well as revascularization of damaged bone through the induction of migration, proliferation, differentiation, and stabilization of endothelial cells into new blood vessels, and restoration of damaged osteochondral tissues through migration, proliferation, and activation of chondrocytes and osteoblasts.

The aim of this Special Issue is to promote communication among researchers studying classic drugs with novel mechanisms for osteochondral regeneration. We invite investigators to contribute original research articles as well as review articles that will mainly focus on multifunctional active drugs for promoting cartilage and/or bone repair and regeneration.

Potential topics include but are not limited to the following:

• New application fields of classic drugs to promote cartilage repair and regeneration
• New mechanisms of classic drugs to promote cartilage repair and regeneration
• New application fields of classic drugs to promote subchondral bone or bone repair and regeneration
• New mechanisms of classic drugs to promote subchondral bone or bone repair and regeneration
• Adjuvants to increase drug function or activity
• Drug delivery systems to increase drug function or activity
• Novel drugs to promote cartilage repair and regeneration
• Novel drugs to promote subchondral bone or bone repair and regeneration