BioMed Research International

The Role of Autophagy in Liver Diseases: Mechanisms and Potential Therapeutic Targets


Status
Published

Lead Editor

1Service de Chirurgie Digestive et Transplantation Hépatique, Hôpital l'Archet 2, Inserm U1065-C3M, Equipe 2, Université de Nice Sophia Antipolis, Nice, France

2Inserm U1065-C3M, Equipe 2, Université de Nice Sophia Antipolis, Nice, France

3Inserm U845, Necker Medical School, Paris Descartes University, Paris, France


The Role of Autophagy in Liver Diseases: Mechanisms and Potential Therapeutic Targets

Description

Autophagy, or cellular self-digestion, is a cellular pathway crucial for the development, differentiation, survival, and homeostasis of cells. Many autophagy-involved proteins had been identified as being modulated by posttranslational mechanisms, including posttranslational modification, protein-protein interactions, and protein cleavage. Normal liver function requires hepatocellular basal autophagy. Due to their high biosynthetic activity and role in protein and carbohydrate storage, hepatocytes may be particularly dependent on basal autophagy.

In normal liver physiology, as well as in several liver diseases, autophagy plays a critical role. For example, autophagy might play a dual role in cancer development: autophagy can serve as an antitumor mechanism, as defective autophagy promotes the malignant transformation and spontaneous tumors. On the other hand, autophagy functions as a protective or survival mechanism in cancer cells against cellular stress (e.g., nutrient deprivation, hypoxia, and DNA damage) and hence promotes tumorigenesis and causes resistance to therapeutic agents. Autophagy seems to play an important role in the pathogenesis of liver diseases such as nonalcoholic and alcoholic fatty liver, drug-induced liver injury, protein aggregate-related liver diseases, viral hepatitis, fibrosis, aging, ischemia-reperfusion liver injury, and liver cancer.

Understanding the molecular mechanisms underlying autophagy modulation and liver disease development may provoke the translational studies that ultimately lead to new therapeutic strategies for liver diseases.

We invite investigators to contribute original review articles and research articles that will underline the role of autophagy in liver diseases and that will improve strategies to target, follow, and treat liver diseases. Potential topics include, but are not limited to:

  • Autophagy in liver physiology and metabolism
  • Autophagy and genetic liver disease
  • Autophagy and acute liver injury
  • Autophagy and liver ischemia-reperfusion injury
  • Autophagy and viral hepatitis
  • Autophagy in alcoholic liver disease
  • Autophagy and nonalcoholic fatty liver disease
  • Autophagy and liver tumors
  • Autophagy and immunologic liver disorders
  • Druggable targets: in the present and future

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/hepatology/ald/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 480508
  • - Editorial

The Role of Autophagy in Liver Diseases: Mechanisms and Potential Therapeutic Targets

Raffaele Cursio | Pascal Colosetti | ... | Han-Ming Shen
  • Special Issue
  • - Volume 2015
  • - Article ID 417590
  • - Review Article

Autophagy and Liver Ischemia-Reperfusion Injury

Raffaele Cursio | Pascal Colosetti | Jean Gugenheim
  • Special Issue
  • - Volume 2014
  • - Article ID 120179
  • - Review Article

Autophagy and Non-Alcoholic Fatty Liver Disease

Vanessa J. Lavallard | Philippe Gual
  • Special Issue
  • - Volume 2014
  • - Article ID 869390
  • - Review Article

Autophagy: A Multifaceted Partner in Liver Fibrosis

Ariane Mallat | Jasper Lodder | ... | Sophie Lotersztajn
  • Special Issue
  • - Volume 2014
  • - Article ID 701064
  • - Review Article

Liver Autophagy in Anorexia Nervosa and Acute Liver Injury

Marouane Kheloufi | Chantal M. Boulanger | ... | Pierre-Emmanuel Rautou
  • Special Issue
  • - Volume 2014
  • - Article ID 265353
  • - Review Article

Autophagy in HCV Infection: Keeping Fat and Inflammation at Bay

Tiziana Vescovo | Giulia Refolo | ... | Gian Maria Fimia
  • Special Issue
  • - Volume 2014
  • - Article ID 810401
  • - Research Article

Uncoupling Protein 2 Regulates Palmitic Acid-Induced Hepatoma Cell Autophagy

Jiaxin Lou | Yunjiao Wang | ... | Ying Jiang
  • Special Issue
  • - Volume 2014
  • - Article ID 498491
  • - Review Article

Autophagy in Alcohol-Induced Multiorgan Injury: Mechanisms and Potential Therapeutic Targets

Yuan Li | Shaogui Wang | ... | Wen-Xing Ding
  • Special Issue
  • - Volume 2014
  • - Article ID 459823
  • - Review Article

Capitalizing on the Autophagic Response for Treatment of Liver Disease Caused by Alpha-1-Antitrypsin Deficiency and Other Genetic Diseases

Andrew S. Chu | David H. Perlmutter | Yan Wang
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
 Submit