Genomic Instability, Inflammation and Cancer
1Department of Histology and Embryology, Medical School, University of Athens, Athens, Greece
2ICREA, Institute for Research in Biomedicine, Barcelona, Spain
3Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
4Molecular & Cellular Biology Laboratory, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece
Genomic Instability, Inflammation and Cancer
Description
Genomic instability is an evolving hallmark of cancer. In hereditary cancers, it is an important event driving tumor formation. In sporadic carcinomas, large-scale analyses demonstrate that aberrations of growth-regulating genes may lead to genomic instability that in turn fuels cancer progression. Recent studies support that several inflammatory mediators induce genomic instability providing clues for the increased cancer risk in chronic inflammatory conditions. Data from humans and mouse models suggest that the immune system has both a bright and a dark side in carcinogenesis. Clarifying which immune functions are culprits for tumor promotion and which participate in immunosurveillance is vital in order to exploit this knowledge therapeutically.
We invite authors to provide original research and review articles that highlight the link between inflammation and genomic instability in both humans and rodents. We are particularly interested in articles examining the molecular pathways involved in the induction of genomic instability in chronic inflammatory conditions; the role of the innate and adaptive inflammatory compartment in genomic instability and cancer progression; current concepts on how the immune system can be exploited for cancer therapy focusing on ongoing preclinical and clinical studies. Potential topics include, but are not limited to:
- Preclinical and clinical studies using reagents that target components of the immune system in cancer therapy
- Studies with mouse models examining the effect of the immune system in cancer development
- Advances in biomarkers/prognostic factors of the immune system related with anti-tumor- or tumor-promoting activity
- Molecular pathways implicated in the induction of genomic instability in chronic inflammatory conditions
- Innate versus adaptive immunity and genomic instability
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