Hepatocellular carcinoma (HCC), one of the leading causes for cancer-related deaths, is the most aggressive and lethal liver tumor. The exact mechanisms responsible for the malignant growth and metastatic behaviors of HCC cells remain largely uncovered. Over the past decade, numerous studies have highlighted how noncoding RNAs (ncRNAs) such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) play crucial roles in the development of HCC. Other ncRNAs, such as circular RNAs (circRNAs), PIWI-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), transcribed ultraconserved regions (T-UCRs), and large intergenic noncoding RNAs (lincRNAs), are emerging as key elements of hepatocarcinogenesis. Furthermore, extracellular vesicles (EVs) are implicated in cell-to-cell communication by transferring ncRNAs species including miRNAs, lncRNAs, and circRNAs. Cumulative evidence suggests that EV-associated ncRNAs are important mediators in a range of digestive diseases, particularly in cancer biology where they function through regulating expression of the genes contributing to tumor development. This special issue strives to provide a platform for gathering original and review articles about all aspects of ncRNAs and their biogenesis, regulation, and role in HCC.

Potential topics include but are not limited to the following:

• ncRNAs as diagnostic and prognostic biomarkers of HCC
• Hypoxia and ncRNAs
• ncRNAs regulation of proliferation, apoptosis, autophagy, angiogenesis, invasion, and metastasis in HCC
• Role of extracellular vesicles associated ncRNAs in disease development and biomarker studies
• ncRNAs based therapies
• Role of ncRNAs as epigenetic modifiers in HCC